For sufferers with inflammatory bowel illness (IBD), threat elements related to Clostridioides difficile an infection (CDI) embrace latest prognosis, corticosteroid utilization, and hospitalization, in response to a research printed on-line Feb. 17 in Therapeutic Advances in Gastroenterology.
Krista Vitikainen, from Helsinki College Hospital, and colleagues carried out a case-control cohort research of sufferers with IBD with and with out CDI episodes to look at scientific threat elements for CDI and its recurrence. The research included 279 sufferers with IBD and CDI. Medical historical past and IBD-related signs three months previous a toxin-positive CDI have been recorded and in comparison with sufferers with IBD who didn’t have CDI (matched for intercourse and age).
The researchers discovered that IBD was energetic earlier than CDI primarily based on scientific signs and fecal calprotectin ranges. The chance for CDI was elevated with lately recognized IBD. CDI episodes have been continuously preceded by corticosteroid utilization (64%). There was no affiliation seen for superior therapies with CDI.
In 30% of the episodes, antibiotic consumption was not registered earlier than CDI. Thirty % of the sufferers with IBD and CDI have been hospitalized earlier than the first CDI. Recurrent CDI occurred in 30% of sufferers with IBD and CDI; two-thirds of those episodes have been registered inside 90 days of the earlier episode. Total, 79% of sufferers with recurrent CDI had ulcerative colitis.
“The prior use of corticosteroids, hospitalization, and the presence of gastrointestinal symptoms before CDI likely indicate an underlying IBD flare, suggesting that inadequate disease control may contribute to the risk of CDI,” the authors write.
A number of authors disclosed ties to the pharmaceutical trade.
Extra info:
Krista Vitikainen et al, Greater illness exercise of inflammatory bowel illness predisposes to Clostridioides difficile an infection, Therapeutic Advances in Gastroenterology (2025). DOI: 10.1177/17562848251318292
© 2025 HealthDay. All rights reserved.
Quotation:
IBD exercise could improve threat for Clostridioides difficile an infection (2025, March 5)
retrieved 5 March 2025
from https://medicalxpress.com/information/2025-03-ibd-clostridioides-difficile-infection.html
This doc is topic to copyright. Aside from any honest dealing for the aim of personal research or analysis, no
half could also be reproduced with out the written permission. The content material is offered for info functions solely.
