Incident use of gabapentin is just not related to a rise in fall-related hospital visits in contrast with duloxetine use, based on a examine revealed on-line Jan. 7 within the Annals of Inner Drugs.
Alexander Chaitoff, M.D., M.P.H., from the College of Michigan College of Drugs in Ann Arbor, and colleagues describe the danger for fall-related outcomes in older adults with diabetic neuropathy, postherpetic neuralgia, or fibromyalgia beginning gabapentin versus duloxetine remedy.
The analytic cohort included 57,086 older adults initiating remedy with gabapentin (52,152 adults) or duloxetine (4,934 adults). The researchers discovered that the weighted cumulative incidence charges of a fall-related go to at 30, 90, and 180 days have been 103.60, 90.44, and 84.44 per 1,000 person-years, respectively, for gabapentin customers and 203.43, 177.73, and 158.21 per 1,000 person-years, respectively, for duloxetine customers.
A decrease hazard of falls was seen for incident gabapentin customers at six-month follow-up (hazard ratio, 0.52), however no distinction was seen within the danger for experiencing extreme falls. Throughout sensitivity and subgroup analyses, the outcomes have been related.
“Incident gabapentin use, compared with incident duloxetine use, was associated with fewer fall-related health care visits and smaller differences in absolute measures and was not associated with an increase in more severe fall-related events,” the authors write. “These considerations should be incorporated into conversations with patients who are considering starting gabapentin treatment.”
Extra info:
Alexander Chaitoff et al, Assessing the Danger for Falls in Older Adults After Initiating Gabapentin Versus Duloxetine, Annals of Inner Drugs (2025). DOI: 10.7326/ANNALS-24-00636
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Incident gabapentin use not linked to extend in falls vs. duloxetine (2025, January 7)
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