The incidence of gentle intraocular irritation (IOI) in the actual world happens extra often after intravitreal injection of aflibercept than in scientific trials, in accordance with a research revealed on-line Might 1 in JAMA Ophthalmology.
Karoline E. Binder, M.D., from the Technical College of Munich, and colleagues assessed the incidence of IOI after intravitreal injection of aflibercept, 8 mg, in real-world follow. The evaluation included 41 sufferers (23 with neovascular age-related macular degeneration and 18 with diabetic macular edema) who had been handled with 136 intravitreal aflibercept, 8 mg, injections.
The researchers reported that 5 sufferers developed gentle sterile IOI inside one to 3 days after the intervention (incidence per injection, 3.7%; incidence per affected person, 12%). Just one affected person developed irritation after the primary dose, whereas the opposite 4 had prior publicity to aflibercept. All sufferers had been handled with native anti-inflammatory remedy (topical or subconjunctival corticosteroids), whereas two sufferers obtained further systemic oral corticosteroids. After IOI resolved, there was no discount in best-corrected visible acuity.
“Although the IOI found in this series can be considered mild, careful evaluation of patient-associated risk factors and thorough patient education are warranted,” the authors write.
A number of authors disclosed ties to the pharmaceutical business.
Extra data:
Karoline E. Binder et al, Noninfectious Intraocular Irritation After Intravitreal Aflibercept, JAMA Ophthalmology (2025). DOI: 10.1001/jamaophthalmol.2025.0969
Quotation:
Intraocular irritation extra widespread with aflibercept injections in real-world setting (2025, Might 9)
retrieved 10 Might 2025
from https://medicalxpress.com/information/2025-05-intraocular-inflammation-common-aflibercept-real.html
This doc is topic to copyright. Aside from any honest dealing for the aim of personal research or analysis, no
half could also be reproduced with out the written permission. The content material is offered for data functions solely.
