The Prognostic Dietary Index (PNI) and systemic oxidative stress (SOS) rating are independently related to poorer prognosis of low-risk myelodysplastic syndrome (MDS), based on a examine printed on-line July 4 within the Journal of Medical Drugs.
Tuba Ersal, M.D., from Bursa Uludag College in Turkey, and colleagues carried out a retrospective evaluation involving 175 newly recognized sufferers with low-risk MDS to look at the prognostic influence of irritation, dietary standing, and oxidative stress at analysis.
The researchers discovered unbiased associations for a low PNI and a excessive SOS rating with poorer prognosis (hazard ratios, 1.598 and 1.003, respectively). For predicting mortality, the optimum PNI cutoff worth was 47.47. Total, 92 and 83 sufferers had a high and low PNI rating, respectively, based mostly on this cutoff. Evaluating these teams demonstrated a big distinction in median total survival, with 45.5 and 75.1 months for the low- and high-PNI teams, respectively. There was no vital affiliation for PNI with development to acute myeloid leukemia. A number of components had been recognized as unbiased predictors of prognosis in a multivariate total survival evaluation, together with a excessive Revised Worldwide Prognostic Scoring System rating, low PNI, excessive SOS rating, superior age, male gender, and transformation to acute myeloid leukemia.
“These findings suggest that anti-inflammatory or antioxidant therapies may play a role in slowing disease progression in MDS,” the authors write. “Prospective, multicenter studies are warranted to validate their generalizability and support their integration into routine clinical practice.”
Extra info:
Tuba Ersal et al, Prognostic Worth of Irritation and Vitamin-Primarily based Scores in Low-Threat Myelodysplastic Syndrome: A Retrospective Cohort Examine, Journal of Medical Drugs (2025). DOI: 10.3390/jcm14134751
Quotation:
Irritation and nutrition-based scores tied to prognosis of low-risk myelodysplastic syndrome (2025, July 24)
retrieved 24 July 2025
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