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The present kidney transplant waitlisting criterion relies on a single measurement of kidney perform (estimated glomerular filtration price [eGFR] ≤20 ml/min/1.73 m2) and doesn’t take into account a person’s danger of progressing to kidney failure.
A brand new examine reveals that inclusion of a affected person’s two-year danger of development to kidney failure (utilizing the Kidney Failure Danger Equation [KFRE], which includes age, intercourse, urine albumin, and eGFR) as a decision-making software towards pre-emptive itemizing for kidney transplantation, has the potential to enhance affected person outcomes and cut back racial disparities. The findings had been offered at ASN Kidney Week 2025, held November 5–9.
When analyzing the usage of the two-year danger of development to kidney failure of ≥25% primarily based on the KFRE as a list criterion and evaluating it with the present eGFR ≤20 criterion, investigators discovered that amongst 10,368 US veterans with persistent kidney illness in 2022 who would meet at the least one of many standards, 60% met each and 20% met just one or the opposite.
In 2022, veterans who solely certified by the eGFR ≤20 criterion had been older (71 years) than those that solely qualify by KFRE ≥25% (53 years).
Additionally, utilizing the kidney illness development standards solely, extra males, minorities (Hispanic, Black, and Asian), and people with diabetes and/or albuminuria can be waitlisted. When analyzing longitudinal knowledge (2006–2019) to evaluate outcomes, the group who met each standards or the KFRE ≥25% solely, had the very best charges of kidney failure and decrease mortality in contrast with those that solely met the eGFR ≤20 criterion.
“Expanding the waitlisting criteria for kidney transplantation to include risk of kidney failure prioritizes individualized approaches to care and could improve outcomes in younger patients with chronic kidney disease, as well as improve racial parity in access to kidney transplantation,” stated corresponding writer Jennifer L. Bragg-Gresham, MS, Ph.D., of the College of Michigan Medical College.
“This approach will continue to be studied prospectively and in populations beyond veterans to verify its potential to improve patient outcomes.”
Extra info:
Optimizing timing for kidney transplant wait-listing.
Offered by
American Society of Nephrology
Quotation:
Kidney transplant waitlisting: A probably higher strategy to optimize the timing (2025, November 8)
retrieved 8 November 2025
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