Distribution of modifications in SER (a) and AL (b) of HAL and ESVL teams throughout 5 follow-up years, and distribution of SER (c) and AL (d) in HAL and ESVL teams after 5 years. AL, axial size; SER, spherical equal refraction; HAL, spectacle lenses with extremely aspherical lenslets; ESVL, extrapolated single-vision spectacle lenses. Credit score: Eye and Imaginative and prescient
A five-year scientific examine has revealed that spectacle lenses outfitted with extremely aspherical lenslets (HAL) can considerably gradual the development of myopia and axial elongation in kids. The findings are printed within the journal Eye and Imaginative and prescient.
In comparison with an extrapolated management group, HAL lenses lowered myopia development by 1.75 diopters (D) and axial elongation by 0.72 mm, successfully decreasing the danger of growing excessive myopia (−6.00 D or worse) by fourfold. These findings mark a essential development in long-term myopia administration, providing a secure and non-invasive intervention amid a rising world imaginative and prescient disaster.
With practically half the world’s inhabitants projected to be myopic by 2050, HAL lenses could maintain the important thing to stopping severe problems corresponding to retinal detachment and glaucoma. Myopia, already affecting over 30% of the worldwide inhabitants, is on the rise—fueled by way of life shifts together with elevated display publicity and lowered time spent outside. In kids, unchecked development usually results in excessive myopia, which dramatically raises the danger of irreversible imaginative and prescient impairment.
Present interventions—corresponding to atropine eye drops and specifically designed contact lenses—face limitations: long-term knowledge is scarce, accessibility stays uneven, and moral constraints limit using untreated management teams in pediatric trials. This underscores an pressing want for scalable, evidence-based options that may safely curb the development of myopia from an early age.
Within the examine, a staff from Wenzhou Medical College’s Eye Hospital reported five-year outcomes from kids utilizing extremely aspherical lenslets (HAL) lenses. The examine included 43 kids and employed an revolutionary extrapolated management mannequin to navigate the moral challenges of long-term pediatric trials.
The outcomes have been compelling: myopia development within the HAL group was −1.27 D, versus −3.03 D in controls. Axial elongation, a key marker of myopia severity, was 0.67 mm with HAL lenses versus 1.40 mm within the management group. That is among the many first research to robustly exhibit the long-term efficacy of optical interventions for myopia management.
Performed as a five-year randomized trial, the examine adopted 43 kids aged 8 to 13 who wore HAL spectacles, monitoring their outcomes in opposition to an extrapolated management group knowledgeable by historic knowledge. HAL lenses slowed myopia development by 58%, and axial elongation by 52%. Strikingly, solely 9% of kids within the HAL group developed excessive myopia, in comparison with 38% within the management cohort—a fourfold discount in danger.
The extrapolated management mannequin, fastidiously validated in opposition to real-world trial knowledge, provided a rigorous but moral answer for long-term pediatric analysis. Notably, the slowing of myopia development turned extra pronounced over time, hinting at cumulative results. Youthful kids confirmed stronger responses, in line with age-related developments in myopia improvement. Security profiles have been robust, with no reported adversarial results corresponding to dizziness or blurred imaginative and prescient.
Whereas the examine’s modest pattern dimension and reliance on modeled controls past two years are famous limitations, its alignment with impartial research—such because the LAMP trial on low-dose atropine—reinforces its credibility. HAL lenses stand out as a sensible, efficient and secure long-term intervention for managing childhood myopia.
“Our results confirm HAL lenses as a viable long-term option for myopia control,” mentioned Dr. Jinhua Bao, co-lead writer of the examine. “While larger trials are warranted, this work provides a valuable framework for ethical, long-term pediatric eye care research.”
Myopia skilled Mark Bullimore, who was not concerned within the examine, commented, “The extrapolated control design is a novel approach. For real-world implementation, it will be important to assess the cost-effectiveness of HAL lenses in various health care settings.”
With their non-invasive design and ease of integration into customary imaginative and prescient care, HAL lenses might reshape public well being methods focusing on myopia, significantly in high-incidence areas corresponding to Asia. In contrast to pharmacologic or contact lens alternate options, HAL lenses supply scalability with out the identical obstacles to make use of. Furthermore, this examine units a brand new precedent for using modeled management teams in long-term pediatric trials.
Wanting forward, researchers purpose to discover the synergy between HAL lenses and different interventions—like elevated outside exercise—in addition to real-world adherence patterns. As myopia prevalence continues to climb, options like HAL lenses could play a pivotal position in assuaging the long-term well being and financial burdens of excessive myopia.
Extra info:
Xue Li et al, Myopia management efficacy of spectacle lenses with extremely aspherical lenslets: outcomes of a 5-year follow-up examine, Eye and Imaginative and prescient (2025). DOI: 10.1186/s40662-025-00427-3
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Wenzhou Medical College
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Lengthy-term knowledge assist aspherical lenslets as efficient myopia management in youngsters (2025, April 3)
retrieved 3 April 2025
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