Lithium is related to an elevated threat for thyroid dysfunction and persistent kidney illness (CKD) in sufferers with incident bipolar dysfunction (BD), in response to a examine revealed on-line Feb. 11 in JAMA Community Open.
Joe Kwun Nam Chan, Ph.D., from the College of Hong Kong, and colleagues examined the chance for thyroid and kidney dysfunction in sufferers aged 15 years or older with incident BD handled with lithium and different temper stabilizers and antipsychotics in an Asian inhabitants in Hong Kong.
General, 4,752, 4,500, and seven,029 people had analyzable information for hypothyroidism, hyperthyroidism, and CKD, respectively. The researchers discovered that in contrast with nonlithium therapies, lithium was related to an elevated threat for hypothyroidism and CKD3+ (adjusted hazard ratios, 2.00 and 1.35, respectively), however not with CKD4+ or end-stage kidney illness.
Elevated charges of hypothyroidism, hyperthyroidism, and CKD3+ had been seen in affiliation with larger lithium serum ranges (adjusted hazard ratios, 2.08, 1.81, and a pair of.11, respectively). There was an affiliation seen for a larger variety of lithium toxicity episodes with elevated CKD3+ threat.
In contrast with lithium, valproate, olanzapine, quetiapine, and risperidone typically exhibited a decrease probability of thyroid dysfunction and CKD3+, with no distinction in superior CKD. Imply lithium serum ranges >0.5028, >0.5034, and >0.5865 mEq/L represented thresholds related to hypothyroidism, hyperthyroidism, and CKD3+, respectively.
“Our findings further identified thresholds of lithium serum levels associated with thyroid and kidney abnormalities, thereby providing empirical evidence to inform clinical guidelines on recommending lithium treatment that balances the efficacy and safety,” the authors write.
A number of authors disclosed ties to the pharmaceutical and medical expertise industries.
Extra info:
Joe Kwun Nam Chan et al, Lithium for Bipolar Dysfunction and Danger of Thyroid Dysfunction and Persistent Kidney Illness, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2024.58608
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Lithium linked to threat for thyroid dysfunction, persistent kidney illness in bipolar dysfunction (2025, February 12)
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