Electrophysiological recording and behavioral duties. Credit score: Microsystems & Nanoengineering (2024). DOI: 10.1038/s41378-024-00778-2
A analysis group led by Prof. Cai Xinxia from the Aerospace Info Analysis Institute (AIR) of the Chinese language Academy of Sciences developed a brand new technique for fabricating high-precision, low-curvature microelectrode arrays (MEAs), that are designed for recording neuronal actions within the mind’s deep small quantity area. The examine was printed in Microsystems & Nanoengineering.
Animals have a pure navigation system that directs them to locations essential for his or her survival. John O’Keefe, together with the couple Might-Britt Moser and Edvard Moser who received the Nobel Prize in Physiology or Medication in 2014, has used microfilament electrodes to find particular cells within the mind—place cells and grid cells—situated within the hippocampus and entorhinal cortex which assist with spatial navigation. Precisely implanting electrodes within the deeper mind areas such because the ventral tegmental space (VTA) has been difficult.
On this examine, researchers launched an progressive bottom dry etching technique to launch residual stress of MEAs, permitting for exact management of electrode bend course from optimistic to unfavourable. They’ll create low-curvature MEAs by exactly adjusting sure parameters.
To substantiate the effectiveness of this technique, researchers used simulation and histological strategies, and located vital enchancment in stress distribution and implantation accuracy of the low-curvature MEAs. This technique exhibits a greater efficiency when it comes to curvature than the superior neural probe Neuropixels.
Within the goal-directed navigation activity, researchers implanted the low-curvature MEAs into the VTA of rats, and recorded the motion trajectory of rats alongside the electrophysiological exercise of VTA neurons. By analyzing each time and place knowledge, they discovered particular discharge patterns and adaptive adjustments within the VTA neurons concerning rewards and spatial info. Notably, the disappearance and reconstruction of the place fields had been linked to shifts within the relationship between path taken and outcomes achieved.
The examine develops low-curvature MEAs with improved temporal and spatial decision, which boosts implantation accuracy and sign high quality for deep mind neuron info detection. It additionally gives insights into the position of VTA in goal-directed navigation.
Extra info:
Wei Xu et al, Neuronal exercise within the ventral tegmental space throughout goal-directed navigation recorded by low-curvature microelectrode arrays, Microsystems & Nanoengineering (2024). DOI: 10.1038/s41378-024-00778-2
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Low-curvature microelectrode arrays document spatial cognitive info coding within the deep mind (2024, November 29)
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