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Individuals with low ranges of low-density lipoprotein ldl cholesterol (LDL-C) of their blood have a decrease threat of dementia, together with decrease threat of Alzheimer’s disease-related dementia, reveals a research printed on-line within the Journal of Neurology Neurosurgery & Psychiatry.
Use of statins conveyed a further protecting impact for individuals with low LDL-C, particularly these with blood ranges lower than 1.8 mmol/L (
Nevertheless, decreasing LDL-C to very low ranges under 0.8 mmol/L (
The advantages of low LDL-C ranges to guard towards cardiovascular occasions is properly acknowledged, however the relationship between LDL-C ranges and dementia has been much less clear, notably the cut-off for LDL-C under which there is no such thing as a additional profit for decreasing threat of cognitive decline.
To deal with this, the authors accessed knowledge collected by 11 college hospitals on grownup outpatients with no earlier prognosis of dementia adopted for at the least 180 days after LDL-C testing. They recognized 192,213 individuals with LDL-C ranges lower than 1.8 mmol/L (130mg/dL), and matched people in every group into 108,980 matched pairs.
Evaluation of subsequent diagnoses of dementia confirmed that LDL-C ranges under 1.8 mmol/L (130mg/dL).
The protecting impact towards cognitive decline lessened at decrease LDL-C ranges and finally disappeared completely. At LDL-C ranges under 1.4 mmol/L (130mg/dL), and when LDL-C ranges fell under 0.8 mmol/L (
Statin use conferred further safety towards dementia within the presence of low LDL-C ranges. Amongst individuals with LDL-C ranges under 1.8 mmol/L (
That is an observational research, and as such, no agency conclusions will be drawn about trigger and impact. The authors additionally acknowledge that the research has some limitations, together with the potential for unmeasured confounding elements due to its retrospective design, doable underreporting of dementia instances attributable to variations in diagnostic accuracy between hospitals, and the give attention to baseline LDL-C ranges when lipid profiles may change over time.
However, the authors conclude, “Low LDL-C levels (disease-related dementia, with statin therapy providing additional protective effects.”
They add, “These findings underscore the crucial role of managing LDL-C in lowering dementia risk.”
Extra info:
Low-density lipoprotein levels of cholesterol and threat of incident dementia: a distributed community evaluation utilizing widespread knowledge fashions, Journal of Neurology Neurosurgery & Psychiatry (2025). DOI: 10.1136/jnnp-2024-334708
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British Medical Journal
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Low LDL levels of cholesterol linked to decreased threat of dementia (2025, April 1)
retrieved 1 April 2025
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