Mice born from dams with artificially induced periodontitis (MatOP) are susceptible to creating inflammatory bowel illness. Credit score: Cell Reviews (2025). DOI: 10.1016/j.celrep.2025.115974
A brand new research demonstrates that maternal oral dysbiosis will increase the danger of intestinal irritation in offspring. Particularly, periodontal illness promotes the expansion of oral pathobionts (e.g., Klebsiella aerogenes), that are then transmitted to the toddler intestine.
This transmission alters intestine immunity and will increase susceptibility to T-cell-dependent enteritis. Though these maternally transmitted oral pathobionts are eradicated because the intestine microbiota matures, the susceptibility to enteritis persists into maturity.
The research, revealed within the journal Cell Reviews, means that sustaining a wholesome maternal microbiota in websites apart from the intestine (e.g., oral cavity) is essential for shaping a wholesome offspring intestine microbiota and for long-term well being.
It additionally signifies that the immature intestine microbiota in infants permits for the ectopic colonization of maternally transmitted oral pathobionts, which in flip alters T-cell immunity and contributes to the exacerbation of enteritis.
Cross-fostering experiments recommend that postnatal publicity to maternal oral pathobionts has a better influence on predisposing offspring to exacerbated enteritis than maternal systemic irritation throughout being pregnant.
Moreover, the research implies that the colonization of Okay. aerogenes alone doesn’t worsen enteritis, suggesting that “pathogenic imprinting” from the mom performs a extra vital position in inducing illness susceptibility.
In abstract, this analysis highlights the long-term influence of maternal oral microbiota well being on toddler intestine well being, deepening our understanding of the affect of non-intestinal maternal microbes on offspring well being.
Extra info:
Masafumi Haraguchi et al, Transmission of maternal oral pathobionts to the toddler intestine predisposes offspring to exacerbated enteritis, Cell Reviews (2025). DOI: 10.1016/j.celrep.2025.115974
Supplied by
College of Osaka
Quotation:
Maternal periodontal illness linked to toddler intestine irritation and long-term illness danger (2025, August 12)
retrieved 13 August 2025
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