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Ladies who expertise menopause earlier than the age of fifty—and particularly earlier than the age of 45—usually tend to develop fatty liver illness and its associated metabolic danger components inside one yr after menopause, in line with analysis introduced on the first Joint Congress between the European Society of Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE). This research is the most important to evaluate this affiliation over 5 years and means that the age of pure menopause needs to be thought-about a part of the cardiometabolic danger evaluation in ladies.
Most girls expertise menopause between the ages of 45 and 55 as a pure a part of organic ageing. After menopause, ladies are at a better danger of long-term well being issues similar to fatty liver illness and its associated metabolic danger components—also referred to as metabolic dysfunction-associated steatotic liver illness (MASLD), a situation attributable to a build-up of fats within the liver. MASLD danger sharply will increase across the common age of menopause, however the precise affiliation between the age at menopause and MASLD is unclear.
On this research, researchers from the Hadassah Medical Heart and The Hebrew College of Jerusalem in Israel examined 89,474 ladies and grouped them in line with their age at menopause: 40–44 years, 45–49 years and those that had not but gone via menopause by age 50. The researchers discovered that ladies who skilled menopause aged 40–44, which is classed as early, had a 46% larger danger of fatty liver illness inside one yr after menopause.
As well as, early menopause was related to an 11% elevated probability of pre-diabetes and weight problems, a 14% elevated danger of hypertension, and a 13% elevated danger of dyslipidemia (unhealthy ranges of lipids within the bloodstream). Equally, ladies aged 45–49 who entered menopause (classed as early-normal) had a 30% larger danger of fatty liver illness and 16% larger danger of pre-diabetes than these ladies who had not entered menopause.
Earlier research haven’t proven the identical affiliation between menopause timing and MASLD. That’s to say, ladies who expertise menopause earlier than the age of 45 have a better danger of growing fatty liver illness and its metabolic danger components, together with hypertension and weight problems. “Previous research on this association has reached conflicting results but was limited by small numbers of participants and short follow-up,” mentioned lead creator Dr. Joshua Stokar.
“Our study is the largest of its kind with a five-year follow-up period and provides support for the hypothesis that women are relatively protected from cardiometabolic disease during the perimenopausal state,” mentioned Dr. Stokar. “We believe our findings justify considering an earlier age at menopause—specifically before the age of 45—as a risk factor for MASLD.”
The researchers will subsequent assess the results of hormone substitute remedy (HRT) in ladies transitioning to menopause and girls who’ve skilled menopause. “Based on our findings that women with earlier menopause are at greater risk for MASLD, we believe a clinical trial is justified to investigate whether HRT could mitigate this risk in this population,” mentioned Dr. Stokar.
He added, “With the aging of the population, as well as the increase in prevalence of obesity and metabolic risk factors, such intervention may reduce the burden of cardiometabolic morbidity in post-menopausal women.”
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Menopause at an earlier age will increase danger of fatty liver illness and metabolic issues (2025, Might 10)
retrieved 10 Might 2025
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