Metabolic syndrome (MetS) is related to an elevated danger for Parkinson’s illness (PD), in accordance with a examine revealed on-line Aug. 20 in Neurology.
Xinjie Zhang, from Sichuan College in Chengdu, China, and colleagues carried out a potential cohort examine involving adults with out PD aged 37 to 73 years from the U.Ok. Biobank to look at the affiliation of MetS and its parts with the danger for PD. MetS was outlined because the presence of three or extra of the next: elevated waist circumference, hypertension, dyslipidemia, hypertriglyceridemia, and hyperglycemia. The PD-related polygenic danger rating (PRSPD) was calculated based mostly on the presence of 26 PD-related alleles and was categorized as low, average, or excessive.
The examine included 467,200 contributors, 37.97% with MetS. The researchers discovered that 3,222 contributors developed PD throughout follow-up (5.01 per 10,000 person-years). For contributors with MetS versus these with out MetS, the hazard ratio of PD was 1.39. There was a dose-dependent affiliation seen for having a better variety of MetS parts and elevated PD danger (hazard ratio, 1.14).
The best PD danger was seen for contributors with MetS and excessive PRSPD (hazard ratio, 2.58). In a meta-analysis of 24,789,538 contributors with 98,582 incident circumstances of PD, contributors with MetS had a pooled relative danger of 1.29 for PD.
“Our findings suggest that metabolic syndrome may be a modifiable risk factor for Parkinson’s disease,” co-author Weili Xu, Ph.D., of the Karolinska Institutet in Stockholm, stated in an announcement. “Future studies are needed to see whether working to control metabolic syndrome could help prevent Parkinson’s disease.”
Extra data:
Xinjie Zhang et al, Metabolic Syndrome and Incidence of Parkinson Illness, Neurology (2025). DOI: 10.1212/WNL.0000000000214033
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Metabolic syndrome linked to elevated danger for Parkinson’s illness (2025, August 21)
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