Fusobacterium varium and Faecalibacterium prausnitzii exhibit cell-to-cell contact. Credit score: Osaka Metropolitan College
Intestinal micro organism are essential for human well being as they assist digest meals and regulate immune operate. Thus, lately, it has develop into clear that intestine microbiota dysbiosis, an imbalance in sorts and composition of intestinal micro organism, is related to digestive problems and different ailments. Nevertheless, the mechanism by which micro organism work together within the gut to take care of the microbiota steadiness stays unclear.
A analysis group led by Affiliate Professor Koji Hosomi at Osaka Metropolitan College’s Graduate College of Veterinary Science studied two micro organism: Fusobacterium varium (F. varium), an oral and intestinal bacterium linked to irritation and colon most cancers, and Faecalibacterium prausnitzii (F. prausnitzii), an intestinal bacterium that produces butyrate, a useful compound for well being.
The research is printed in Microbiome.
The analysis workforce used stool samples from 236 individuals. The workforce then analyzed the interactions between these micro organism utilizing subsequent technology sequencing (NGS) and mass spectrometry.
The outcomes revealed that F. prausnitzii inhibits the expansion of F. varium. This impact is as a result of elevated acidity and quantity of β-hydroxybutyric acid brought on by F. prausnitzii. In distinction, F. varium promotes the expansion of F. prausnitzii. This interplay is more likely to happen by means of direct contact between these micro organism.
“Going forward, further clarification of the relationships between these bacteria could provide new insights into medical and health methods for improving the intestinal environment and find new methods for preventing or improving intestinal disorders and diseases. Further understanding these bacteria could pioneer the development of foods and supplements that enhance the power of bacteria to support gut health,” said Professor Hosomi.
Extra data:
Koji Hosomi et al, Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii, Microbiome (2025). DOI: 10.1186/s40168-025-02168-w
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Osaka Metropolitan College
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Micro organism within the digestive system may fit to take care of steadiness each instantly and not directly (2025, August 1)
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