The mini-brain samples are safely saved within the laboratory. They’re so tiny that they have to be examined within the microscope. Credit score: College of Bergen
Researchers on the College of Bergen have used superior stem cell expertise to develop mini-brains, additionally referred to as mind organoids, that may mimic illness processes attributable to mitochondrial failure. This might open new avenues for treating critical mind illnesses equivalent to epilepsy.
Mitochondria are essential for supplying the mind with vitality. When mitochondrial operate fails, this may result in critical issues within the mind, which require quite a lot of vitality to operate.
Utilizing mini-brains, a analysis workforce led by Kristina Xiao Liang on the Division of Medical Medication, College of Bergen, has been capable of research how genetic mutations in mitochondria have an effect on mind cells and different cell sorts. Their work is printed within the journal Superior Science.
“The mini-brains give us a unique opportunity to understand disease mechanisms at the cellular level and test potential treatments. This is a significant step towards developing new therapies for diseases like severe epilepsy,” says Liang.
Kristina Xiao Liang is Group Chief in Mitochondrial Stem Cell Analysis Group on the College of Bergen. Credit score: College of Bergen
To construct the mini-brains, the scientists coax clusters of stem cells into turning into neurons and different mind cells. This presents a singular software for learning human mind growth and the results of issues. Credit score: College of Bergen
As well as, the analysis can contribute to a greater understanding of different mind illnesses equivalent to Alzheimer’s and Parkinson’s illness. The mini-brains provide a precious mannequin for exploring complicated illness processes and testing remedy methods in a practical however managed setting.
“These diseases often involve mitochondrial dysfunction that can be studied in the mini-brains. They allow researchers to study disease progression in real time, test personalized therapies, and identify new drug targets. While they are still under development, they have shown that we can increase our understanding and treatment of these conditions, potentially revolutionizing the field,” says Liang.
Extra info:
Anbin Chen et al, Hallmark Molecular and Pathological Options of POLG Illness are Recapitulated in Cerebral Organoids, Superior Science (2024). DOI: 10.1002/advs.202307136
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Mini-brains reveal how mitochondrial mutations have an effect on mind cells (2024, December 13)
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