A substantial proportion of sufferers with high-grade serous most cancers (HGSC) have missed alternatives for danger evaluation with genetic testing and for surgical prevention, in line with a research revealed on-line August 13 in JAMA Surgical procedure.
Sara Moufarrij, M.D., from the Memorial Sloan Kettering Most cancers Heart in New York Metropolis, and colleagues examined the frequency of missed alternative for salpingectomy with/with out oophorectomy amongst sufferers identified with HGSC in a retrospective research carried out between 2015 and 2021 (1,877 sufferers). Missed alternative was outlined as a historical past of sterilization procedures at any age or abdomino-pelvic surgical procedures at age 45 years or older when salpingectomy may have been carried out one 12 months or longer earlier than a analysis of HGSC. As well as, an digital survey was administered to members of a nationwide ovarian most cancers group who self-identified as having had an HGSC analysis; 348 of the 917 respondents had been identified with HGSC.
The researchers discovered that of the 445 sufferers with missed alternatives for salpingectomy within the retrospective cohort, 54.2% and 45.8% had a tubal ligation/hysterectomy and had different abdomino-pelvic surgical procedures, respectively. In contrast with youthful sufferers, cholecystectomy, hernia restore, and bowel surgical procedures had been extra generally carried out for sufferers aged 45 years or older. Missed alternative was reported by 15.5% of the 348 survey respondents. Amongst sufferers with an affected first-degree relative within the retrospective cohort, there was a 43.2% missed alternative fee for germline genetic testing and reflex risk-reducing surgical procedure.
“As we deepen our understanding of the pathogenesis and risk factors for cancers arising directly or indirectly from the fallopian tube, the future of ovarian cancer prevention is poised to evolve toward targeted salpingectomy based on polygenic risk modeling and individualized risk stratification,” the authors write.
A number of authors disclosed ties to the biopharmaceutical and publishing industries.
Extra info:
Sara Moufarrij et al, Gauging the Magnitude of Missed Alternative for Ovarian Most cancers Prevention, JAMA Surgical procedure (2025). DOI: 10.1001/jamasurg.2025.2810
Lauren Gilgannon et al, Opportunistic Salpingectomy, JAMA Surgical procedure (2025). DOI: 10.1001/jamasurg.2025.2818
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Missed alternative frequent in sufferers with high-grade serous ovarian most cancers (2025, August 15)
retrieved 15 August 2025
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