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The human genome is broadly labeled into the genome residing within the cell nucleus (nuclear DNA) and the genome residing within the mitochondria (mitochondrial DNA: mtDNA). Mitochondria are cell organelles that produce power important for all times actions by oxidative phosphorylation (mitochondrial respiration), and mtDNA encodes a set of genes required for mitochondrial respiration.
Earlier analysis has led to the broadly accepted speculation that the buildup of a number of mutations in mtDNA with getting older induces a decline in mitochondrial respiratory operate, ensuing within the “mitochondrial theory of aging.” However, whether or not the lower in mitochondrial respiratory operate is definitely on account of these amassed mutations has not been definitively established.
On this examine, researchers demonstrated that mitochondrial respiratory operate isn’t impaired even when wild-type mice amassed mtDNA mutations to the identical extent as in untimely getting older mannequin mice.
The findings are revealed within the journal Growing older Cell.
These outcomes counsel that the decline in mitochondrial respiratory operate isn’t instantly brought on by mtDNA mutations alone. Moreover, the outcomes name for a reinvestigation of the “mitochondrial theory of aging.”
The analysis workforce will proceed to discover how varied mutations amassed in mtDNA contribute to signs of untimely getting older, aiming to increase our understanding of the connection between getting older and mitochondrial dysfunction.
Extra info:
Hiroaki Tamashiro et al, Mitochondrial Respiratory Dysfunction Is Not Correlated With Mitochondrial Genotype in Untimely Growing older Mice, Growing older Cell (2025). DOI: 10.1111/acel.70085
Offered by
College of Tsukuba
Quotation:
Mitochondrial DNA mutation accumulation might not be a figuring out think about getting older (2025, Might 23)
retrieved 23 Might 2025
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