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Utilizing tirzepatide and menopause hormone remedy on the similar time results in elevated weight reduction in postmenopausal ladies with obese or weight problems in contrast to make use of of tirzepatide remedy alone, in keeping with a research being offered Saturday at ENDO 2025, the Endocrine Society’s annual assembly in San Francisco, Calif.
“These data are the first to show the combined use of tirzepatide and menopause hormone therapy significantly increases treatment effectiveness in postmenopausal women,” stated Regina Castaneda, M.D., analysis fellow for the Division of Endocrinology on the Mayo Clinic in Jacksonville, Fla.
“Previous studies of the medication semaglutide found similar results. Achieving these outcomes with a second obesity medication may indicate a broader efficacy trend for pairing these two classes of medications.”
Menopause-related hormonal modifications usually end in elevated belly fats, decreased muscle mass and altered power expenditure, which results in weight acquire and places tens of millions of ladies in danger for creating coronary heart illness and different critical well being points.
To substantiate the speculation that concurrent menopause hormone remedy enhances the effectiveness of tirzepatide for weight reduction in postmenopausal ladies, researchers performed a real-world research utilizing the digital medical data of 120 postmenopausal ladies over a median length of 18 months. The research included two cohorts: 40 ladies utilizing menopause hormone remedy concurrently with tirzepatide and 80 ladies utilizing tirzepatide alone.
The outcomes confirmed superior whole physique weight reduction proportion for ladies utilizing tirzepatide plus menopause hormone remedy (17%) in comparison with these utilizing tirzepatide alone (14%). As well as, the next proportion of menopause hormone remedy customers (45%) additionally achieved no less than 20% whole physique weight reduction, in comparison with 18% of menopause hormone remedy non-users.
“The information garnered through this new study provides important insights to develop more effective and personalized weight management interventions to reduce a postmenopausal woman’s risk of overweight and obesity-related health complications,” stated Maria Daniela Hurtado Andrade, M.D., Ph.D., assistant professor of drugs and advisor for the Division of Endocrinology on the Mayo Clinic.
“This study underscores the urgent need for further research to better understand how obesity medications and menopause hormone therapy work together. Gaining this knowledge could greatly improve the health and well-being of millions of postmenopausal women. It also points to the need for better strategies to make these treatments more accessible and available to those who need them.”
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The Endocrine Society
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Mixture of weight problems remedy tirzepatide and menopause hormone remedy fuels weight reduction (2025, July 12)
retrieved 12 July 2025
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