A short neurocognitive battery is possible to be used in 3-year-olds throughout acute lymphoblastic leukemia remedy, in line with a research printed on-line Dec. 9 in Pediatric Blood & Most cancers.
Sameera Ramjan, from Memorial Sloan Kettering Most cancers Heart in New York Metropolis, and colleagues provided sufferers enrolled within the Remedy of Newly Identified Acute Lymphoblastic Leukemia in Youngsters and Adolescents participation in an non-compulsory neurocognitive research assessing longitudinal modifications in neurocognitive perform. The evaluation included 3- and 4-year-old sufferers enrolled within the research.
The researchers discovered that 3-year-old sufferers didn’t differ from 4-year-olds by way of their potential to carry out or full the temporary Cogstate battery assessing psychomotor perform (detection) and a spotlight (identification). These findings endured at 4 time-point assessments, by means of 52 weeks after prognosis.
“This report demonstrates that computerized testing, such as Cogstate, can be successfully administered to 3-year-old patients who are undergoing treatment for acute lymphoblastic leukemia, thereby capturing serial test data on a vulnerable patient population that, in prior studies, have demonstrated worse neurocognitive deficits,” the authors write.
“Consequently, changing future study inclusion criteria to include patients diagnosed at the age of 3 years will ultimately serve to improve our understanding of at-risk patients and the neurocognitive trajectory of this age group both during treatment as well as into survivorship, thereby leading to the development of early interventions.”
One creator disclosed ties to the pharmaceutical trade; two authors disclosed ties to Cogstate.
Extra data:
Sameera Ramjan et al, Feasibility of Using a Transient Neurocognitive Battery in 3‐Yr‐Previous Sufferers Throughout Remedy for Acute Lymphoblastic Leukemia, Pediatric Blood & Most cancers (2024). DOI: 10.1002/pbc.31469
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Neurocognitive battery possible in 3-year-olds throughout leukemia remedy (2024, December 18)
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