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A groundbreaking examine led by Nationwide Jewish Well being researchers means that the pores and skin could function a possible biomarker for a persistent allergic illness of the esophagus referred to as eosinophilic esophagitis (EoE) in kids. The outcomes present physicians a possible new, noninvasive avenue to diagnose EoE through the use of pores and skin tape.
This examine by Elena Goleva, Ph.D. and Donald Y. Leung, MD, Ph.D. of Nationwide Jewish Well being, in collaboration with Seema Aceves, MD, Ph.D., on the College of California San Diego, centered on ceramides—lipid molecules important for sustaining the pores and skin’s protecting barrier. Outcomes, now printed within the Journal of Allergy and Medical Immunology, show that the pores and skin of youngsters with EoE however with out atopic dermatitis (eczema) present important deficits in long-chain and ultralong-chain ceramides in comparison with wholesome controls.
“This research provides the first evidence that skin barrier lipid abnormalities exist in EoE, even in the absence of visible skin disease,” stated Dr. Goleva. “Our findings support the idea of a unified epithelial barrier dysfunction underlying allergic diseases of both the skin and the esophagus.”
EoE is an inflammatory, meals allergen–pushed illness characterised by immune-mediated harm to the esophageal lining. It’s typically seen in sufferers with different allergic situations reminiscent of eczema and meals allergic reactions. Nonetheless, no dependable surrogate noninvasive markers presently exist for figuring out EoE threat—significantly in kids with out overt pores and skin signs.
“This study paves the way for using noninvasive skin tape stripping as a potential diagnostic or screening tool for EoE—eliminating the need for endoscopy,” stated Dr. Leung. “By analyzing skin lipid profiles, we may be able to detect epithelial vulnerability before symptoms appear. If validated, this simple skin test could revolutionize how we diagnose and monitor eosinophilic esophagitis.”
The analysis workforce used superior lipidomics evaluation through liquid chromatography with tandem mass spectrometry on pores and skin samples collected through tape strips from the forearms of examine individuals.
The outcomes underscore the chance that EoE and eczema—whereas manifesting in numerous tissues, share a standard origin in faulty lipid metabolism and epithelial barrier dysfunction. This new analysis has broader implications for treating and monitoring allergic illnesses in childhood.
Extra data:
Elena Goleva et al, Cutaneous ceramide synthesis is dysregulated in pediatric eosinophilic esophagitis, Journal of Allergy and Medical Immunology (2025). DOI: 10.1016/j.jaci.2025.02.024
Offered by
Nationwide Jewish Well being
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New analysis hyperlinks pores and skin barrier dysfunction to pediatric eosinophilic esophagitis (2025, June 7)
retrieved 7 June 2025
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