[18F]RCCB6 and 18F-FDG PET/CT imaging in affected person with superior NPC. (A) [18F]RCCB6 immuno-PET/CT photographs exhibiting major NPC (pink arrowhead) and a number of systemic metastases, together with cervical lymph nodes (yellow arrowheads), bone (inexperienced arrowhead), lung (orange arrowhead), liver (blue arrowhead), and Omental bursa lymph nodes (pink arrowhead) in affected person 20. (B) 18F-FDG PET/CT photographs of similar affected person, demonstrating corresponding lesions. Credit score: B. Shi and W. Wei et al. Renji Hospital, College of Drugs, Shanghai Jiao Tong College.
A novel immuno-PET/CT imaging method has recognized and validated a potent biomarker for nasopharyngeal most cancers (NPC). The biomarker, CD70, is extremely and consistently expressed in NPCs, and CD70-targeted immuno-PET/CT has confirmed efficient in precisely detecting major and metastatic NPC lesions.
This analysis, printed in The Journal of Nuclear Drugs, has the potential to reinforce prognosis and information personalised therapies for NPC sufferers.
NPC is a sort of head and neck most cancers that’s discovered within the higher a part of the throat, behind the nostril and by the bottom of the cranium. Whereas NPC is uncommon, it’s extra widespread in sure components of South Asia, the Center East, and North Africa. NPC is related to the Epstein-Barr virus (EBV)—a typical herpesvirus that causes mononucleosis—and far analysis focuses on this relationship.
“We know that the biomarker CD70 is crucial in the immune response to EBV infection,” famous Weijun Wei, MD, Ph.D., affiliate analysis professor within the Division of Nuclear Drugs at Renji Hospital College of Drugs, Shanghai Jiao Tong College, in Shanghai, China.
“Since many NPC cases are associated with EBV infection, we sought to further investigate the role and diagnostic potential of this biomarker.”
Within the research, CD70 expression was analyzed in 80 archived NPC specimens and correlated with medical and pathologic options. Utilizing 18F-RCCB6, a single-domain antibody–derived tracer particular for human CD70, the diagnostic efficacy of 18F-RCCB6 immuno-PET/CT was assessed in 25 sufferers with NPC and in contrast with that of 18F-FDG PET/CT.
CD70 was positively expressed in 90% of NPC specimens, with expression ranges strongly correlated with EBV. In sufferers, 18F-RCCB6 uptake correlated properly with CD70 expression. 18F-RCCB6 immuno-PET/CT achieved a 100% detection fee of the first tumor and a 93% detection fee of native lymph node metastasis in sufferers with early-stage illness.
In comparison with 18F-FDG, 18F-RCCB6 demonstrated greater sensitivity in detecting lymph node metastasis and equal detection talents for major lesions and most distant metastases.
Notably, 18F-RCCB6 immuno-PET/CT demonstrated higher analysis of skull-base invasion with a transparent border and bone metastases.
“These findings are critical for improving NPC management,” famous Wei.
“18F-RCCB6 immuno-PET/CT presents exact detection of major tumors, metastases, and recurrent lesions, lowering false positives from inflammatory uptake seen with 18F-FDG.
“This accuracy can enhance radiotherapy planning and guide personalized therapies, such as CD70-targeted immunotherapies. For patients, this translates to earlier detection, reduced overtreatment, and better prognostication.”
Extra info:
Binyu Shi et al, CD70-Focused [18F]RCCB6 Immuno-PET/CT Imaging in Sufferers with Nasopharyngeal Carcinoma: A Proof-of-Idea Examine, Journal of Nuclear Drugs (2025). DOI: 10.2967/jnumed.125.269585
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New PET imaging method offers exact mapping of nasopharyngeal most cancers biomarker (2025, June 13)
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