Kari Stefansson and Gudmundur Einarsson authors of a brand new research that explores the position of BMI in illness threat. Credit score: JG/deCODE genetics
Scientists at deCODE genetics have printed a research in Nature Communications that sheds gentle on how physique mass index (BMI) influences the chance of varied ailments which might be comorbid with weight problems. The research, which used genetic knowledge from Iceland and the UK Biobank, checked out whether or not illness dangers related to BMI-related sequence variants are defined utterly or partially by their impact on BMI.
The outcomes confirmed that for some situations, similar to fatty liver illness, glucose intolerance, and knee alternative, the genetic hyperlink to illness disappeared when BMI was taken into consideration. For different situations, like kind 2 diabetes, coronary heart failure, and stroke, the consequences have been largely lowered however not completely defined by BMI.
The research discovered related patterns in women and men, though there have been some variations, particularly for myocardial infarction (coronary heart assault), suggesting that intercourse might play a job in how BMI influences illness threat. The scientists additionally famous that different components, similar to adjustments in BMI over time slightly than BMI measured at one cut-off date or different components strongly correlated with BMI, may clarify a number of the remaining threat.
This analysis highlights the significance of BMI within the pathogenesis of ailments which might be extra widespread in overweight individuals than others, suggesting that simply decreasing BMI may decrease the chance of those ailments.
Extra data:
Sequence variants related to BMI have an effect on illness threat by BMI itself, Nature Communications (2024). DOI: 10.1038/s41467-024-53568-9
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deCODE genetics
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New research explores the position of BMI in illness threat (2024, November 12)
retrieved 12 November 2024
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