Abundance of MAIT cells throughout the human physique. Graphical content material modified from biorender.com. Credit score: Tobias Kammann, “The diversity of MAIT cells across the human body and in COVID-19.”
Tobias Kammann from the Middle for Infectious Medication (CIM) on the Division of Medication, Huddinge (MedH) is defending his thesis titled “The diversity of MAIT cells across the human body and in COVID-19,” on 29 November, 2024. His predominant supervisor is Johan Sandberg (MedH).
What’s the predominant focus of your thesis?
My analysis explored the roles of a particular group of immune cells known as mucosal-associated invariant T (MAIT) cells. These cells have been found comparatively just lately and most of what we learn about them stems from analysis on blood samples.
In my thesis, we investigated these cells intimately in human tissues donated to analysis, which allowed us to characterize the function of this cell kind in several elements of the human physique, such because the liver, the lung, and the intestines. Additionally, we investigated the involvement of MAIT cells in extreme COVID-19 and the way these cells recuperate in individuals recovering from the illness.
That are crucial outcomes?
For the primary time, we may quantify the variety of MAIT cells throughout paired blood and a number of organs from the identical particular person. We noticed tissue-dependent distribution patterns and indicators of specialization to the tissue atmosphere.
In research of hospitalized COVID-19 sufferers, we noticed that MAIT cells have been extremely activated and migrating to the infected lung. Within the aftermath of COVID-19, a number of months after restoration and launch from the hospital, we detected that in some people, MAIT cells nonetheless displayed phenotypic alterations and purposeful impairment.
How can this new data contribute to the advance of individuals’s well being?
Learning MAIT cells concurrently in a number of wholesome human tissues allowed us to put out a panorama of those cells for the human tissue immunology and MAIT cell analysis group. A greater understanding of the presence and roles of tissue-resident MAIT cells can result in novel or improved methods to deal with a broad vary of numerous human immune-related ailments.
Our findings on MAIT cells in COVID-19 counsel that MAIT cell activation could be an indicator for sufferers at greater danger of extreme illness.
What are your future ambitions?
When contemplating the situation of the immune system, you would possibly instinctively consider the blood. Nevertheless, nearly all of our immune system really resides exterior of the blood, inside our tissues, and we perceive a lot much less about it there. I want to proceed engaged on altering that and carry on exploring human tissue-resident T cell immunity.
Extra data:
Thesis: The range of MAIT cells throughout the human physique and in COVID-19
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Karolinska Institutet
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New thesis on MAIT cells offers insights into immunity and COVID-19 (2024, November 21)
retrieved 21 November 2024
from https://medicalxpress.com/information/2024-11-thesis-mait-cells-insights-immunity.html
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