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An evaluation from the Section III CheckMate 77T trial confirms that perioperative nivolumab doesn’t compromise health-related high quality of life (HRQoL) in sufferers with resectable non-small cell lung most cancers (NSCLC), together with these with Stage III N2 illness.
These outcomes had been introduced on the Worldwide Affiliation for the Examine of Lung Most cancers 2025 World Convention on Lung Most cancers (WCLC).
The examine assessed HRQoL by nodal standing and surgical outcomes utilizing patient-reported end result (PRO) measures such because the NSCLC-Symptom Evaluation Questionnaire (NSCLC-SAQ) and the EQ-5D-3L visible analog scale (VAS). Sufferers obtained both neoadjuvant nivolumab plus chemotherapy or placebo plus chemotherapy, adopted by surgical procedure and adjuvant remedy.
“Maintaining quality of life during and after treatment is vital to long-term success, and these results show that perioperative nivolumab supports both survival and patient well-being,” mentioned Dr. Jonathan Spicer from McGill College Well being Middle.
He reported that greater than 90% PRO completion charges throughout nodal standing teams, besides at pre- and post-surgery, and that well being care high quality of life was typically maintained throughout all therapy phases.
Moreover, Dr. Spicer mentioned that amongst Stage III N2 NSCLC sufferers, nivolumab decreased danger of HRQoL deterioration vs. placebo NSCLC-SAQ: HR = 0.50 (95% CI: 0.28–0.88) and EQ-5D-3L VAS: HR = 0.47 (95% CI: 0.27–0.82).
“These benefits extended to patients undergoing single lobectomy or complete resection,” he mentioned.
The analyses reinforce the function of perioperative nivolumab as a therapy that not solely extends event-free survival but additionally protects affected person high quality of life in early-stage resectable NSCLC, significantly amongst high-risk N2 sufferers, Dr. Spicer said.
Offered by
Worldwide Affiliation for the Examine of Lung Most cancers
Quotation:
Nivolumab maintains high quality of life and reduces symptom deterioration in resectable NSCLC, trial exhibits (2025, September 6)
retrieved 6 September 2025
from https://medicalxpress.com/information/2025-09-nivolumab-quality-life-symptom-deterioration.html
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