Knowledge seize overview. (A) Quantitative compression ultrasound (QCU) imaging information assortment flowchart (B) A drive time sequence is proven as an example the info assortment methodology. First, drive is ramped from low to excessive till the IJV fully occludes, contributing to the CVP scalar estimate. Segmented QCU pictures of the carotid artery (crimson) and IJV (blue) are proven at low drive and CF. Second, the drive is held fixed with the IJV in a calmly compressed state to seize carotid and IJV information to enter into an inverse mannequin that estimates the CVP waveform. Credit score: Anthony Lab@MIT.
In a scientific pilot research, researchers from the Massachusetts Institute of Expertise (MIT) and Massachusetts Common Hospital (MGH) have validated a novel, noninvasive methodology for measuring central venous strain (CVP) utilizing quantitative compression ultrasound (QCU). This research, printed in BME Frontiers, marks a major development in cardiovascular diagnostics, providing a promising different to conventional invasive catheterization and visible inspection strategies.
The research enrolled 11 sufferers from MGH’s cardiac intensive care unit (CICU), all of whom had indwelling central venous catheters as a part of their normal care. Researchers meticulously captured QCU information, together with short-axis, cross-sectional ultrasound pictures of the inner jugular vein (IJV), alongside simultaneous measurements of the drive utilized to the pores and skin’s floor.
These noninvasive QCU measurements had been then rigorously in comparison with the gold-standard invasive CVP information obtained straight from the sufferers’ central venous catheters. To additional contextualize the findings, jugular venous pulsation top (JVP), a standard noninvasive scientific measure, was additionally recorded in a subset of sufferers for comparative evaluation.
The findings revealed a compelling correlation between the collapse drive (CF)—outlined because the drive required to completely occlude the IJV short-axis cross-section—and invasive CVP measurements. By way of linear regression evaluation, the researchers achieved a powerful r² correlation coefficient of 0.82, with a imply absolute error of simply 1.08 mmHg.
Quantitative compression ultrasound (QCU) video of whole drive sweep and fixed drive from Determine 1. Pressure is in Newtons. The video is performed at-speed (29 frames per second). Credit score: BME Frontiers (2025). DOI: 10.34133/bmef.0115
When accounting for hydrostatic strain offset (HO), the correlation marginally elevated to 0.83. In stark distinction, JVP measurements demonstrated a weaker correlation with invasive CVP, yielding an r² of 0.45 and a imply absolute error of 1.39 mmHg.
The flexibility to noninvasively and precisely estimate CVP carries profound scientific implications. CVP is a crucial parameter within the administration of sufferers with coronary heart failure, sepsis, and different circulatory issues, straight informing therapeutic interventions resembling adjusting vasopressor drugs or administering diuretics.
Whereas conventional invasive strategies provide accuracy, they aren’t with out dangers, together with potential issues, and are resource-intensive. Noninvasive options like JVP, alternatively, are restricted by inter-operator variability and dependence on affected person positioning.
QCU stands out as a game-changing resolution, offering dependable CVP estimates with out the necessity for invasive procedures. This know-how has the potential to streamline scientific workflows, cut back affected person discomfort, and allow extra frequent monitoring, significantly in resource-constrained environments.
This analysis was performed by a collaborative crew from the Massachusetts Institute of Expertise (MIT) and Massachusetts Common Hospital (MGH), Harvard Medical Faculty. The crew comprised Alex T. Jaffe from the Division of Electrical Engineering and Pc Science at MIT, Roger Pallarès-López and Jeffrey Okay. Raines from the Division of Mechanical Engineering at MIT, and Aaron D. Aguirre from the Cardiology Division at MGH, Harvard Medical Faculty. The research was spearheaded by Brian W. Anthony, additionally from the Division of Mechanical Engineering at MIT.
Extra data:
Alex T. Jaffe et al, Noninvasive Quantitative Compression Ultrasound Central Venous Strain: A Medical Pilot Examine, BME Frontiers (2025). DOI: 10.34133/bmef.0115
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Noninvasive ultrasound methodology for measuring central venous strain validated in scientific pilot research (2025, Could 23)
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