Credit score: STAR Protocols (2025). DOI: 10.1016/j.xpro.2025.103699
Cardiovascular researchers at UC Davis Well being have developed a novel approach that enables scientists to check how the mind communicates with different organs, like the guts or intestine. The brand new technique preserves the mind tissue in animal analysis whereas concurrently accumulating dwelling (unfixed) samples from different organs.
Their work seems in STAR Protocols.
Conventional strategies in neuroscience animal research preserved the complete physique, making it not possible to check dwelling tissues from the identical animal.
The brand new technique permits researchers to conduct a number of sorts of analyses—equivalent to histology, useful and molecular research. It makes use of the fastened mind and different unfixed tissues from one experimental animal with out the necessity for quite a few animals.
“This dual-preservation method represents a significant advancement in animal research, maximizing the scientific value of each model while reducing the number of animals needed for comprehensive studies,” mentioned Xiaodong Zhang, professor of cardiovascular medication and corresponding creator of the examine.
This system provides researchers a robust option to examine how the mind interacts with different organs—like the guts or intestine—throughout preclinical research utilizing animal fashions. By preserving the mind whereas holding different organs recent, scientists can now discover advanced mind–physique connections extra successfully than ever earlier than.
“This method is not only versatile and easy to use, thanks to its simple tools and adaptability across different animal models, but also cost-effective,” added Zhang. “It allows us to conduct multiple types of studies using the same animal. In the past, each animal could only be used for a single purpose. This means fewer animals, lower costs, and more comprehensive data from each experiment.”
Extra data:
Phung N. Thai et al, Protocol for mouse carotid artery perfusion for in situ mind tissue fixation and parallel unfixed tissue assortment, STAR Protocols (2025). DOI: 10.1016/j.xpro.2025.103699
Quotation:
Novel tissue preservation technique permits mind–physique research in animal analysis (2025, August 21)
retrieved 22 August 2025
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