Use of nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) is related to an elevated danger for main open-angle glaucoma (POAG), in keeping with a research printed on-line June 20 in Ophthalmology.
Kenneth Pham, from the College of Pennsylvania in Philadelphia, and colleagues carried out a retrospective cohort research involving 305,441 adults aged 40 years or older with linked digital well being file information from the Nationwide Institutes of Well being All of Us dataset to evaluate the affiliation of NRTI use with POAG. A cohort of 1:10 NRTI customers to nonusers was created utilizing a propensity score-matching design; 718 people with NRTI use have been recognized and matched with 7,180 nonusers.
The researchers discovered that the speed of POAG was 4.32% in NRTI customers and a couple of.00% within the propensity score-matched management group. POAG danger was elevated in affiliation with NRTI use (odds ratio, 2.21). NRTI use remained considerably related to an elevated danger of creating POAG after adjustment for residual imbalance of household historical past of POAG, HIV prognosis, and hepatitis B prognosis (odds ratio, 1.84). NRTIs remained considerably related to POAG danger after matching and adjusting for self-reported eye physician visits (odds ratio, 2.30).
“A possibility that could explain the association between NRTI use and POAG risk is that increased medical surveillance associated with NRTI use could allow greater opportunity for POAG diagnosis, though we have performed multiple analyses to detect such a mechanism,” the authors write.
“Moreover, analyses for cataracts and angle-closure glaucoma did not reveal an association between NRTI use and those other eye conditions. Together, these results do not find evidence that higher POAG rates observed among NRTI users can merely be attributed to more examination of the eyes.”
Extra info:
Kenneth Pham et al, Affiliation between nucleoside and nucleotide reverse transcriptase inhibitor use and first open-angle glaucoma danger in All of Us, Ophthalmology (2025). DOI: 10.1016/j.ophtha.2025.06.014
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NRTI use linked to danger for main open-angle glaucoma (2025, July 8)
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