OA reduces HeLa cell viability together with CPT. Credit score: Worldwide Journal of Molecular Sciences (2024). DOI: 10.3390/ijms252413475
Researchers describe a brand new potential position for oleanic acid as a modulator of the DNA injury response following camptothecin remedy. Administration of oleanic acid together with camptothecin for most cancers chemotherapy might cut back the quantity of drug wanted and improve the effectiveness of remedy. The findings are a part of a novel analysis program targeted on figuring out new molecules for most cancers remedy derived from pure extracts.
The research, titled “Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death,” was revealed final week within the Worldwide Journal of Molecular Sciences.
The analysis group is led by Prof. Antonio Giordano, M.D., Ph.D., Director of the Sbarro Institute for Most cancers Analysis and Molecular Drugs at Temple College, Professor of Pathology on the College of Siena, and Founding father of the Sbarro Well being Analysis Group (SHRO), together with Dr. Luigi Alfano from the Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy.
Researchers working with SHRO and Giordano have been chargeable for quite a few groundbreaking discoveries in molecular biology and precision drugs, together with capsaicin’s potential to reinforce mesothelioma remedy, a research concerning the position of CDK9 in oncology, and a genetic goal to scale back blood vessel development in glioblastoma tumors.
On this new research, oleanic acid was recognized in a grape pomace extract utilizing Nuclear Magnetic Resonance (NMR), revealing a major impact on the viability of most cancers cell strains when mixed with a chemotherapeutic drug. The addition of oleanic acid acts as an additive compound with camptothecin, lowering the required focus of the chemotherapeutic drug in comparison with camptothecin alone. Furthermore, oleanic acid doesn’t have an effect on cell viability on the concentrations utilized in these experiments.
“This is an important discovery for our group, highlighting the potential of natural extracts as a source of molecules for cancer therapy,” says Alfano.
“Use of oleanic acid may allow us to reduce the camptothecin drug concentration needed to get the desired anti-cancer result,” says senior writer Giordano. “Lower doses of chemotherapy suggest the possibility of reducing the side effects associated with cancer treatment, making the experience more tolerable for patients.”
Extra data:
Giulio Mazzarotti et al, Oleanolic Acid Modulates DNA Harm Response to Camptothecin Growing Most cancers Cell Dying, Worldwide Journal of Molecular Sciences (2024). DOI: 10.3390/ijms252413475
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Sbarro Well being Analysis Group (SHRO)
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Oleanolic acid from grapes might improve chemotherapy effectiveness (2024, December 30)
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