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One shot of an RSV vaccine protects adults aged 60 or older from RSV-associated hospitalization and significant sickness throughout two consecutive RSV seasons, in line with a examine revealed in JAMA by the IVY Community analysis group.
RSV causes substantial seasonal sickness throughout fall and winter within the U.S., with an estimated 100,000–150,000 hospitalizations and 4,000–8,000 deaths occurring yearly amongst adults 60 or older.
The outcomes reinforce the suggestions for RSV vaccines in older adults and lay the groundwork for understanding how lengthy a single dose of the vaccine could also be efficient, in line with Wesley Self, MD, MPH, principal investigator for the IVY Community and Senior Vice President for Scientific Analysis at Vanderbilt College Medical Heart.
“These results clearly demonstrate that the RSV vaccines prevent hospitalizations and critical illness due to RSV infection among older Americans,” Self mentioned. “It is exciting to see the public health benefits of this new vaccination program.”
Investigators used information from a multicenter hospital community often called the IVY Community (The Investigating Respiratory Viruses within the Acutely In poor health Community) to evaluate RSV vaccine effectiveness. They used a test-negative, case-control examine design amongst 6,958 individuals 60 years or older who had been hospitalized with acute respiratory sickness at one among 26 hospitals in 20 US states throughout two RSV seasons from October 1, 2023–March 31, 2024 and October 1, 2024–April 30, 2025.
General, vaccination diminished the danger of RSV hospitalization by 58% throughout two RSV seasons, together with 69% within the first yr after vaccination and 48% within the second yr after vaccination.
“Our data show that the beneficial effects of RSV vaccines appear to wane over time,” Self mentioned. “Redosing the vaccine at some interval after the initial dose could be a strategy to maintain protection over longer periods of time. It will be important to continue to closely monitor vaccine effectiveness over time to understand how long the benefit lasts after a single dose and if repeat dosing should be considered.”
Present RSV vaccine suggestions are for all adults aged 75 years and older and people aged 60–74 years who’re at an elevated threat of extreme RSV.
Extra data:
One shot of an RSV vaccine protects adults ages 60 or older from RSV-associated hospitalization and significant sickness throughout two consecutive RSV seasons, in line with a examine revealed in JAMA at this time by the IVY Community analysis group., JAMA (2025). DOI: 10.1001/jama.2025.15896
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Vanderbilt College Medical Heart
Quotation:
One shot of RSV vaccine discovered efficient in opposition to hospitalization in older adults for 2 seasons (2025, August 30)
retrieved 30 August 2025
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