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Helene Lindfors, Ph.D. Scholar on the Endocrine Surgical procedure analysis group, the Division of Molecular Medication and Surgical procedure, will defend her thesis “Tumor burden, thyroglobulin and Ki-67 as prognostic indicators in papillary thyroid cancer” on April 11, 2025. The primary supervisor is Ivan Shabo.
What’s the primary focus of your thesis?
My thesis is about prognostic elements in papillary thyroid most cancers, which is the most typical sort of most cancers within the thyroid gland. Immediately, remedy with surgical procedure and radioiodine is essentially based mostly on the dimensions and anatomical unfold of the illness. We all know at this time from different cancers that the organic properties of the tumor play an vital position within the prognosis of the illness and the consequences of remedy.
The thesis goals to increase data about varied tumor organic markers in papillary thyroid most cancers and their significance for illness recurrence, says Lindfors.
What are a very powerful outcomes?
We have now examined varied medical and histopathological (microscopic) markers in each main tumors and lymph node metastases in sufferers. The analyses present that these markers can distinguish sufferers with an elevated danger of recurrence and that the markers of the lymph node metastasis can differ from these within the main tumor. That is vital info as a result of the extra remedy with radioiodine, which follows surgical procedure, is at present guided by the traits of the first tumor however in apply targets any remaining lymph node metastases.
How can this data contribute to the development of individuals’s well being?
With these markers, danger evaluation for future recurrence in sufferers could be improved, which implies that some sufferers most likely don’t must be adopted as much as the identical extent as at this time as a result of they’ve a really low danger of recurrence. The outcomes may choose a gaggle of sufferers with a clearly worse prognosis who could profit from elevated or modified extra remedy.
What are your future ambitions?
My hope is to proceed analysis on tumor organic markers to extend data and to include them into tips for danger evaluation. It will even be fascinating to research whether or not the markers can be utilized to enhance extra remedy in sufferers with an elevated danger of recurrence.
Extra info:
Helene Lindfors, Tumour burden, thyroglobulin and Ki-67 as prognostic indicators in papillary thyroid most cancers (2025). DOI: 10.69622/28263539.v1
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Karolinska Institutet
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Papillary thyroid most cancers: New markers supply hope for tailor-made remedy (2025, March 27)
retrieved 27 March 2025
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