Scheme of the entire analytical workflow supplied by HTGAnalyzer. Credit score: Laia Díez-Ahijado / ISGlobal
The Barcelona Institute for International Well being (ISGlobal) has launched HTGAnalyzer, a brand new, easy-to-use, quick and reproducible bioinformatics device for superior transcriptomic knowledge evaluation. Designed throughout the R statistical surroundings, this package deal simplifies advanced analytical processes, making them accessible to professionals with out particular experience in bioinformatics.
Transcriptomic evaluation examines all messenger RNA molecules current in a cell at a given time, revealing which genes are expressed and in what amount. This info is essential in precision medication, an method that seeks to tailor therapies to every affected person’s genetic and molecular profile.
Regardless of its scientific potential, the implementation of transcriptomic strategies has been restricted not by knowledge era, however by the complexity of the required bioinformatics evaluation.
A user-friendly device for clinicians and researchers
To handle this problem, the ISGlobal crew has developed HTGAnalyzer: an automatic, free and user-friendly device for clinicians of assorted specialties. Laia Díez-Ahijado was the lead creator of the device, which was collectively conceptualized by Natalia Rakislova and Robert Albero.
The research, printed in Computer systems in Biology and Drugs, demonstrates how HTGAnalyzer simplifies advanced transcriptomic workflows, together with knowledge import and normalization, pattern high quality management, differential gene expression evaluation, purposeful enrichment, tumor microenvironment profiling and survival evaluation. The device makes use of sufferers’ molecular knowledge to determine organic and scientific variations, thereby supporting the scientific interpretation of outcomes.
Validation utilizing real-world oncology knowledge
HTGAnalyzer was validated utilizing a number of datasets, together with RNA-seq knowledge from The Most cancers Genome Atlas (TCGA) and a cohort of sufferers with vulvar most cancers—a uncommon and generally aggressive malignancy.
Within the latter case, the device recognized differentially expressed genes, described their immunological profiles, and revealed genes and mobile pathways linked to this most cancers and to affected person survival. These findings spotlight the scientific potential of HTGAnalyzer for producing information relevant to most cancers prognosis, remedy, and prognosis.
With this growth, the analysis crew has achieved its aim of bridging the hole between advanced bioinformatic evaluation and the sensible wants of scientific and analysis environments. HTGAnalyzer permits professionals with out superior bioinformatics experience to carry out important transcriptomic analyses which might be more and more being utilized in customized medication to tell prognosis, prognosis, and customized therapies primarily based on the affected person’s molecular biology.
Extra info:
Laia Díez-Ahijado et al, HTGAnalyzer: An accessible R package deal with an online interface for enhanced transcriptomic evaluation in precision medication, Computer systems in Biology and Drugs (2025). DOI: 10.1016/j.compbiomed.2025.110772
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Barcelona Institute for International Well being
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Person-friendly device streamlines transcriptomic knowledge evaluation for precision medication functions (2025, August 8)
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