SEC61B (crimson) is overexpressed in a HEK293 cell line (tubulin in inexperienced, nuclear staining in blue) for purposeful assays. Credit score: College of Sydney
New analysis from the Charles Perkins Middle on the College of Sydney has uncovered a brand new organic pathway which will assist clarify why folks with sort 2 diabetes are extra liable to growing harmful blood clots, doubtlessly paving the best way for future remedies that scale back their cardiovascular danger.
The examine, led by Affiliate Professor Freda Passam from the Central Scientific Faculty and Affiliate Professor Mark Larance from the Faculty of Medical Sciences, is printed within the Journal of Scientific Investigation.
A protein known as SEC61B has been discovered to be considerably elevated within the platelets of individuals with sort 2 diabetes. The protein seems to disrupt calcium stability inside platelets, making them extra prone to clump collectively and kind clots.
Importantly, the researchers confirmed that blocking SEC61B exercise with an antibiotic—anisomycin—diminished platelet clumping in human samples and animal fashions.
“People living with type 2 diabetes are vulnerable to increased risk of blood clots,” mentioned Affiliate Professor Passam. “These exciting findings identify a whole new way to reduce this risk and help prevent life-threatening complications like heart attack and stroke.”
In Australia alone, practically 1.2 million folks have been residing with sort 2 diabetes in 2021. The situation is extra prevalent in Aboriginal and Torres Strait Islander peoples and in rural and regional communities.
SEC61B (crimson) is seen in platelets (inexperienced) in diabetic mice. Credit score: College of Sydney
“Cardiovascular disease is a leading cause of death in this group, partly due to the heightened activity of platelets—the tiny blood cells that help form clots. This heightened platelet sensitivity to clotting also makes traditional anticoagulant treatments less effective in people with type 2 diabetes, limiting the options to reduce the risk of cardiovascular disease.”
The analysis workforce used superior proteomic methods to check human and mouse platelets, discovering that SEC61B contributes to calcium leakage from shops of the mineral inside platelets, which in flip makes platelets extra reactive.
Whereas remedies concentrating on SEC61B are nonetheless in early phases, the researchers consider preclinical trials in animals might start inside one to 2 years, with potential therapies for sufferers on the horizon within the subsequent decade.
Extra data:
SEC61B regulates calcium flux and platelet hyperreactivity in diabetes, Journal of Scientific Investigation (2025). DOI: 10.1172/JCI184597
Supplied by
College of Sydney
Quotation:
Platelet protein might clarify blood clot danger for folks with sort 2 diabetes (2025, August 15)
retrieved 16 August 2025
from https://medicalxpress.com/information/2025-08-platelet-protein-blood-clot-people.html
This doc is topic to copyright. Aside from any truthful dealing for the aim of personal examine or analysis, no
half could also be reproduced with out the written permission. The content material is supplied for data functions solely.
