Prenatal publicity to selective serotonin reuptake inhibitors (SSRIs) is related to an elevated threat of useful constipation growing in offspring, in keeping with a research revealed on-line Dec. 10 in Molecular Psychiatry.
Helene Kildegaard, M.D., from the Hans Christian Andersen Youngsters’s Hospital in Odense, Denmark, and colleagues examined associations between gestational SSRI publicity and offspring issues of gut-brain interplay (DGBI) utilizing population-based registries. All single-birth Danish youngsters born in 1997 to 2015 had been included. Youngsters born to moms who continued SSRIs throughout being pregnant had been in comparison with these whose moms discontinued SSRIs earlier than being pregnant.
Of the 1,158,560 youngsters, 1.9 and a couple of.6 % had been uncovered to SSRIs prenatally and had been born to moms who discontinued SSRIs earlier than being pregnant, respectively. The researchers discovered that the 15-year cumulative incidence of any DGBI was 15.5 and 14.7 % within the SSRI-exposed and unexposed teams, respectively. The chance of DGBIs was elevated total in SSRI-exposed youngsters (hazard ratio, 1.08), with the rise pushed by useful constipation however not by useful nausea and vomiting or useful stomach ache issues.
“Our finding that functional constipation is increased following prenatal SSRI exposure should not be taken as a directive to change clinical practice or current recommendations for antidepressant treatment in pregnancy,” the authors write. “Treating depression in pregnancy is a high priority, as untreated depression can have significant adverse consequences on both the mother and the fetus.”
One creator disclosed ties to the pharmaceutical trade.
Extra data:
Helene Kildegaard et al, Prenatal publicity to selective serotonin reuptake inhibitors and threat of issues of gut-brain interplay in youngsters, Molecular Psychiatry (2024). DOI: 10.1038/s41380-024-02848-3
Quotation:
Prenatal SSRI publicity linked to useful constipation in offspring (2024, December 13)
retrieved 13 December 2024
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