For sufferers with opioid use dysfunction (OUD), proof helps continuation of buprenorphine throughout episodes of acute ache, however general proof for ache outcomes in these sufferers is low, in keeping with a evaluate revealed on-line March 18 within the Annals of Inner Drugs.
Michele J. Buonora, M.D., from the Yale College of Drugs in New Haven, Connecticut, and colleagues carried out a scientific evaluate to look at the advantages and harms of acute ache interventions amongst sufferers with OUD. A complete of 17 trials, 20 managed observational research, and 78 uncontrolled observational research met the standards for eligibility.
The researchers discovered that based mostly on cohort research carried out primarily in perioperative settings, there could also be an affiliation between persevering with use of buprenorphine throughout acute ache episodes with related or improved pain-related outcomes in contrast with discontinuation.
In adults not prescribed drugs for OUD, oral clonidine, intramuscular haloperidol and midazolam with intravenous morphine, and intraoperative intravenous lidocaine could enhance ache outcomes based mostly on single well-conducted randomized managed trials in emergency division or perioperative settings; these findings warrant additional examine in numerous affected person populations. Methadone and the impact of interventions on OUD outcomes had been solely assessed in a small share of research.
“The effects of acute pain management interventions on OUD outcomes have not been well-characterized and merit urgent study in light of the ongoing crisis of opioid-related overdoses and other harms,” the authors write.
Extra info:
Michele J. Buonora et al, Acute Ache Administration in Individuals With Opioid Use Dysfunction, Annals of Inner Drugs (2025). DOI: 10.7326/ANNALS-24-01917
Theresa E. Vettese et al, Navigating Acute Ache Administration for Sufferers With Opioid Use Dysfunction, Annals of Inner Drugs (2025). DOI: 10.7326/ANNALS-25-00410
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Proof helps persevering with buprenorphine for acute ache in these with opioid use dysfunction (2025, March 31)
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