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Individuals who have metabolic and bariatric surgical procedure are considerably much less prone to develop psychiatric problems in comparison with those that take weekly injections of GLP-1 anti-obesity medicines, based on a brand new research offered immediately on the American Society for Metabolic and Bariatric Surgical procedure (ASMBS) 2025 Annual Scientific Assembly. Over a five-year interval, the danger of growing cognitive deficits was 54% decrease and 18% and 17% decrease for nervousness problems and substance use problems, respectively.
“The study shows metabolic and bariatric surgery confers a strong protective effect against common mental health disorders in a head-to-head comparison with GLP-1 pharmacotherapy,” mentioned research co-author Shauna Levy, MD, MS, Assistant Professor, Chief, Division of MIS/Bariatric Surgical procedure, Tulane College Faculty Medication.
“The data supports embedding psychiatric screening and support within both surgical and medical obesity programs to help reduce the potential mental health burden after treatment. Further investigation is needed, however, to determine why the psychological impact is so different between treatment modalities.”
Researchers carried out a retrospective evaluation of metabolic and bariatric surgical procedure sufferers and sufferers on GLP-1 agonists, semaglutide, liraglutide, and dulaglutide, utilizing the TriNetX database. After propensity rating matching to steadiness demographic and scientific traits, 33,600 surgical sufferers and 33,600 pharmacotherapy sufferers have been in contrast for the incidence of latest psychiatric problems. The follow-up interval lasted as much as 5 years.
“Maintaining mental health is important regardless of treatment choice. Even small differences can impact quality of life, so patients and their doctors should be proactive about monitoring mood, cognition, and substance use after starting any obesity therapy. Mental health is just as important as physical health and must be considered along with any treatment,” mentioned Ann M. Rogers, MD, ACS FASMBS, President, ASMBS, who was not concerned within the research.
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American Society for Metabolic and Bariatric Surgical procedure
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Psychiatric problems much less seemingly after weight-loss surgical procedure than therapy with GLP-1s (2025, June 17)
retrieved 17 June 2025
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