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Shruti Gupta, MD, MPH, and David Leaf, MD, MMSc, of the Renal Division, Division of Medication at Brigham and Ladies’s Hospital are the primary and senior authors, respectively, of a paper revealed in JAMA Oncology, “Intravenous Magnesium and Cisplatin-Associated Acute Kidney Injury: A Multicenter Cohort Study.”
On this interview, they talk about their analysis.
How would you summarize your examine?
Cisplatin is a chemotherapy drug used globally for the remedy of a number of cancers; nevertheless, additionally it is extremely poisonous to the kidneys. Past basic supportive measures, there’s minimal knowledge from medical trials relating to preventive therapies for cisplatin-associated kidney injury.
Animal research counsel magnesium could assist the kidneys excrete cisplatin within the urine, thereby defending the kidneys from injury. Nonetheless, knowledge from bigger research in people is missing.
What query have been you investigating?
We examined whether or not receipt of IV magnesium on the identical day as the primary dose of IV cisplatin was related to a diminished danger of cisplatin-associated kidney injury.
What method did you utilize?
We collected knowledge on 13,719 sufferers receiving their first dose of cisplatin between 2006–2022 throughout 5 main most cancers facilities within the U.S. Round 30% of them acquired IV magnesium. We then examined whether or not magnesium receipt was related to a decrease danger of cisplatin-associated kidney damage, making certain we accounted for an in depth listing of key potential confounding variables.
What did you discover?
Sufferers who acquired IV magnesium had a 20% decrease adjusted odds of growing kidney injury from cisplatin in comparison with those that didn’t obtain IV magnesium. Our findings counsel that IV magnesium administration could scale back the incidence of cisplatin-associated kidney injury. These findings have been comparable throughout a variety of subgroup and sensitivity analyses.
What are the implications and subsequent steps?
Our findings counsel that sufferers could profit from receiving IV magnesium previous to receiving IV cisplatin. Magnesium is affordable, secure, and available world wide. Additional, its use within the context of prevention of cisplatin-associated kidney damage is well-supported by animal fashions. Nonetheless, our findings warrant affirmation in a randomized medical trial. There’s presently one underway at Brigham and Ladies’s Hospital.
Extra data:
Shruti Gupta et al, Intravenous Magnesium and Cisplatin-Related Acute Kidney Harm, JAMA Oncology (2025). DOI: 10.1001/jamaoncol.2025.0756
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Mass Normal Brigham
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Q&A: Researchers talk about how IV magnesium reduces kidney injury from cisplatin chemotherapy (2025, April 24)
retrieved 24 April 2025
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