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A research led by UCLA Well being Jonsson Complete Most cancers Heart investigators discovered that stereotactic physique radiotherapy (SBRT), a type of high-dose radiation delivered in simply 5 classes, after prostate surgical procedure is protected and as efficient as conventional, longer programs of radiation in stopping prostate most cancers from returning.
The research is printed within the journal European Urology and offered on the 2025 American Society for Radiation Oncology (ASTRO) Annual Assembly.
After prostate surgical procedure, some males stay prone to their most cancers coming again. Radiation remedy can decrease this threat, however the usual strategy often entails every day remedies for a number of weeks, which might be burdensome for sufferers. Researchers have been exploring whether or not SBRT, already a confirmed possibility for males who haven’t had surgical procedure, is also protected and efficient within the post-surgery setting. Its use has been restricted, nonetheless, due to issues about security and the sensitivity of close by organs.
The SCIMITAR Section 2 trial enrolled 100 sufferers at UCLA and the College of Southern California who had undergone a radical prostatectomy and had been thought-about at increased threat of recurrence. Sufferers acquired SBRT in 5 classes over roughly 10 days, with some additionally receiving hormone remedy or lymph node radiation based mostly on doctor steering. Sufferers had been then monitored for about 4.5 years for most cancers recurrence, unintended effects and high quality of life.
After greater than 4 years of follow-up, researchers discovered:
60% of sufferers remained freed from biochemical recurrence, which means there have been no indicators of most cancers or rise in PSA, and no want for extra hormone remedy
SBRT with out hormone remedy lowered the danger of recurrence in comparison with typical radiation
Uncomfortable side effects had been typically manageable. Severe bowel issues occurred in 7% of sufferers, and urinary points in 32%. Utilizing MRI-guided radiation helped scale back urinary unintended effects even additional
Most sufferers maintained their high quality of life, with minimal adjustments in urinary, bowel and sexual well being.
These outcomes construct on earlier findings, which confirmed that SBRT is protected and handy over a two-year interval. Collectively, the research counsel that SBRT could also be a sooner, easier possibility for males who want radiation after prostate surgical procedure.
“These findings suggest this faster treatment approach could offer an alternative to conventional, longer radiation courses for men at risk of recurrent prostate cancer,” mentioned co-first writer Dr. Amar Kishan, professor and government vice chair of radiation oncology on the David Geffen College of Medication at UCLA and co-director of the most cancers molecular imaging, nanotechnology and theranostics program on the UCLA Well being Jonsson Complete Most cancers Heart.
“Importantly, side effects were manageable in a majority of men, particularly with MRI-guided treatment, and most men were able to maintain their quality of life.”
Extra data:
Amar U. Kishan et al, Stereotactic Depth-modulated Radiotherapy After Radical Prostatectomy (SCIMITAR): 4-12 months Outcomes of a Section 2 Medical Trial, European Urology (2025). DOI: 10.1016/j.eururo.2025.09.4149
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Quick-course radiation remedy after prostate surgical procedure helps preserve most cancers from returning (2025, October 2)
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