Fourteen % of people provoke glucagon-like peptide 1 receptor agonists (GLP-1 RAs) after bariatric surgical procedure, in line with a research printed on-line Aug. 27 in JAMA Surgical procedure.
Minji Kim, Pharm.D., from the Johns Hopkins Bloomberg Faculty of Public Well being in Baltimore, and colleagues characterised the usage of and elements related to GLP-1 RA initiation amongst U.S. adults present process bariatric surgical procedure in a retrospective cohort research. Digital well being data have been obtained from about 113 million U.S. adults.
The researchers discovered that 14.0% of the 112,858 people present process bariatric surgical procedure initiated GLP-1 RAs after surgical procedure, with 21.5% starting inside two years of surgical procedure and the rest initiating throughout postsurgical years 3 to 4, 5 to six, or past (32.3%, 25.2%, and 21.0%, respectively). In contrast with their counterparts, feminine sufferers, these present process sleeve gastrectomy, and people with sort 2 diabetes have been extra more likely to provoke GLP-1 RAs (adjusted hazard ratios, 1.61, 1.42, and 1.34, respectively). There was an 8% improve within the probability of GLP-1 RA initiation with every one-unit improve in postsurgical physique mass index (BMI; adjusted hazard ratio, 1.08).
“These findings raise important questions for future obesity research,” senior research creator Hemalkumar Mehta, Ph.D., additionally from the Johns Hopkins Bloomberg Faculty of Public Well being, mentioned in a press release.
Extra data:
Minji Kim et al, Use of Glucagon-Like Peptide-1 Agonists Amongst People Present process Bariatric Surgical procedure within the US, JAMA Surgical procedure (2025). DOI: 10.1001/jamasurg.2025.3089
Kate V. Lauer et al, The GLP-1 Period—What Comes After Bariatric Surgical procedure?, JAMA Surgical procedure (2025). DOI: 10.1001/jamasurg.2025.3099
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Research finds 14% of U.S. adults provoke GLP-1 receptor agonists after bariatric surgical procedure (2025, September 3)
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