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In a latest multicenter potential examine carried out at three hospitals in Tennessee and Georgia, together with Vanderbilt College Medical Heart, researchers at VUMC discovered a considerable burden of hospitalizations for community-acquired pneumonia (CAP) amongst adults.
Neighborhood-acquired pneumonia refers to a case of the illness contracted with out prior publicity to a well being care setting. This distinguishes CAP from hospital-acquired pneumonia (HAP), which impacts sufferers who contract the illness because of publicity to a well being care setting.
The examine, revealed in JAMA Community Open, included knowledge from 2018 to 2022 and used a novel serotype-specific urinary take a look at that may establish infections brought on by 30 completely different Streptococcus pneumoniae serotypes. A serotype refers to a definite pressure of microorganism, comparable to micro organism.
An necessary facet of the examine was the identification of noninvasive pneumococcal infections, stated Carlos Grijalva, MD, MPH, professor of Well being Coverage and Biomedical Informatics and the examine’s lead creator.
“Standard clinical diagnostic methods such as bacterial cultures of blood are helpful for identifying invasive cases of pneumococcal disease, but the majority of pneumococcal pneumonias are thought to be noninvasive,” Grijalva added. “Using a novel and more sensitive urinary antigen detection method allowed us to identify a number of pneumococcal infections that may have otherwise passed unrecognized.”
Primarily based on present inhabitants estimates, some 114,800 U.S. adults could also be hospitalized for pneumococcal pneumonia annually, a determine made up largely by older adults. And based on the examine’s findings, annually sees roughly 340 hospitalizations for community-acquired pneumonia per 100,000 adults, roughly 14% of which had proof of Streptococcus pneumoniae an infection.
“Our study results show that Streptococcus pneumoniae remains an important cause of severe community-acquired pneumonia,” stated Wesley Self, MD, MPH, professor of Emergency Medication, Senior Vice President for Scientific Analysis and the paper’s senior creator.
Lots of the serotypes recognized by pneumococcal detections corresponded with these coated by a just lately licensed adult-specific pneumococcal conjugate vaccine, V116, which incorporates 21 serotypes however was not commercially obtainable throughout the examine interval.
“Vaccines with coverage of additional pneumococcal serotypes could be quite beneficial in lessening the burden of severe pneumonia in the U.S. population, especially among older adults,” added Self, who holds the Directorship in Emergency Care Analysis.
Extra info:
Carlos G. Grijalva et al, All-Trigger and Pneumococcal Neighborhood-Acquired Pneumonia Hospitalizations Amongst Adults in Tennessee and Georgia, JAMA Community Open (2025). DOI: 10.1001/jamanetworkopen.2025.24783
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Vanderbilt College Medical Heart
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Research finds good portion of grownup pneumonia hospitalizations linked to preventable pneumococcal infections (2025, August 6)
retrieved 6 August 2025
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