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Transmasculine and gender-diverse people who use testosterone usually are not at elevated danger of gynecological most cancers within the first years of hormone remedy. That is evident from large-scale analysis by Amsterdam UMC, which was revealed in eClinicalMedicine.
The outcomes present essential insights for well being care suppliers and transmasculine and gender-diverse people who’re contemplating beginning hormone remedy.
Transmasculine and gender-diverse persons are registered as ladies at delivery, however don’t really feel male, non-binary or in any other case at house throughout the conventional picture of being a girl. Lots of them select to make use of testosterone: a hormone remedy that induces bodily adjustments which are extra consistent with their gender id and/or expression.
Researchers at Amsterdam UMC adopted 1,955 younger transmasculine and gender-diverse people, who used testosterone for a mean of 5 years. They particularly investigated the danger of most cancers of the uterus, ovaries, vagina and vulva throughout testosterone use.
Asra Vestering, researcher at Amsterdam UMC, explains, “We found no increased risk of these cancers compared to women from the general population. None of these cancers were diagnosed in the entire participant group. This is valuable information for both health care providers and transmasculine and gender-diverse people who are considering starting hormone therapy.”
It was additionally putting that in among the members the endometrium was nonetheless energetic, or that indicators of ovulation have been noticed, regardless of using testosterone.
Wouter van Vugt, co-researcher at Amsterdam UMC, explains, “This is not only relevant for long-term health, but also means that despite testosterone use, there is still a chance of pregnancy. That is why good gynecological care and contraceptive care remains essential for this group, even after the start of hormone therapy.”
Lately, gender registration laws within the Netherlands has been relaxed, making surgical gender elimination now not a requirement to legally change gender. Consequently, increasingly transmasculine and gender-diverse persons are selecting to start out hormone remedy first, with out present process intercourse elimination surgical procedure (instantly).
Though no definitive conclusions can but be drawn concerning the results of long-term testosterone use, these findings supply reassurance for people who’ve began or need to begin testosterone use.
Vestering emphasizes, “This research provides important knowledge for better information and guidance of transmasculine and gender-diverse people. At the same time, follow-up research into the effects of long-term testosterone use remains necessary, so that care can be further tailored to safety and quality of life.”
Extra info:
Incidence of Gynaecological (Pre-)Malignancies and Endometrial Exercise in Transmasculine and Gender Various People Utilizing Testosterone: A Retrospective, Single-Centre Cohort Research, eClinicalMedicine (2025).
Offered by
Amsterdam College Medical Facilities
Quotation:
Research finds no elevated danger of gynecological most cancers with testosterone use after 5 years (2025, Might 12)
retrieved 12 Might 2025
from https://medicalxpress.com/information/2025-05-gynecological-cancer-testosterone-years.html
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