A photograph of Natsumeda lab members, together with Dr. Satoshi Shibuma (far left) and Dr. Manabu Natsumeda (far proper). Credit score: Niigata College
A bunch led by the Division of Neurosurgery, Mind Analysis Institute, Niigata College, has succeeded within the prognosis of leptomeningeal illness in diffuse midline gliomas by detecting H3K27M-mutant droplets from circulating tumor DNA of cerebrospinal fluid taken from these sufferers.
The work is printed within the journal Pediatric Blood & Most cancers on January 9, 2025.
In two sufferers, leptomeningeal illness was identified sooner than with conventional strategies reminiscent of MRI and cerebrospinal fluid cytology. In a single affected person, long run survival after the prognosis of leptomeningeal illness by early and aggressive intervention together with surgical procedure, radiation, and intrathecal supply of chemotherapeutic brokers led to long run survival.
A group led by Dr. Manabu Natsumeda used droplet digital PCR, a extremely delicate PCR system, to detect hint quantities of circulating tumor DNA from the cerebrospinal fluid of those sufferers.
“We found that detecting circulating tumor DNA in the cerebrospinal fluid of diffuse midline glioma patients was more difficult than other brain tumor patients such as primary central nervous system lymphoma and glioblastoma,” explains Dr. Natsumeda.
“However, when we were able to detect mutant tumor DNA, often the tumor had already spread to the cerebrospinal fluid, causing leptomeningeal disease. We think that early diagnosis and treatment of leptomeningeal disease in diffuse midline gliomas can improve survival.”
Extra info:
Satoshi Shibuma et al, Analysis of Leptomeningeal Illness in Diffuse Midline Gliomas by Detection of H3F3A K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid, Pediatric Blood & Most cancers (2025). DOI: 10.1002/pbc.31535
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Research succeeds in early prognosis of leptomeningeal illness in diffuse midline gliomas by liquid biopsy (2025, January 27)
retrieved 28 January 2025
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