Credit score: JCI Perception (2025). DOI: 10.1172/jci.perception.193637
A not too long ago accomplished examine signifies that the constructive results of a fatty acid referred to as eicosapentaenoic acid range considerably between people. The examine emphasizes the significance of metabolism within the prevention of cardiovascular illnesses. It’s printed within the journal JCI Perception.
Finnish researchers investigated how eicosapentaenoic acid (EPA), an omega-3 fatty acid obtained from fish oil, impacts wholesome folks’s blood lipid ranges and metabolism.
EPA is thought to scale back heart problems in people with elevated blood lipid ranges or coronary heart illnesses. Nonetheless, info on EPA’s results on wholesome folks has been scarce, as has that on EPA accumulation in lipoproteins, which carry lipids (fatty molecules) in circulation.
Within the examine, 38 contributors got exceptionally excessive doses of EPA dietary supplements, with samples collected earlier than, throughout and after the supplementation. The findings exhibit nice particular person variation in EPA’s results.
“The samples taken during supplementation clearly show the effect of EPA on all participants. Having said that, all samples were different among the group. In other words, each individual has a unique lipoprotein lipidome in their circulation, a ‘lipid fingerprint,’ if you will, that persisted despite EPA supplementation,” says Professor Katariina Öörni, one of many two lead authors of the article, from the School of Organic and Environmental Sciences, College of Helsinki, and the Wihuri Analysis Institute.
EPA successfully absorbed, however blood ranges fall quickly
The examine additionally demonstrated that EPA is successfully absorbed, multiplying its focus within the blood. Nonetheless, the degrees fall quickly after supplementation ends. The strongest responses had been seen in contributors with low baseline EPA ranges.
As well as, EPA improves the blood lipid profile and reduces lipoprotein attachment to elements of the arterial partitions. This discount is essential, as it’s exactly such accumulation that results in atherosclerosis.
Due to the short-term nature of the examine, long-term results stay unknown. The outcomes nonetheless exhibit how EPA modifies blood lipid composition and the danger mechanisms related to atherosclerosis additionally in wholesome people.
“The findings highlight the importance of metabolism in the prevention of cardiovascular diseases. EPA’s effects varied more between individuals than we expected. We also demonstrated that these effects dissipate quickly, which is good to know in case EPA were to have adverse effects,” summarizes Doctoral Researcher Lauri Äikäs.
Subsequent, the researchers will conduct mobile exams to find out how EPA supplementation impacts the functioning of inflammatory cells and particularly the quantity of lipid mediators that suppress irritation.
“It’s interesting to see how, for instance, dietary changes affect lipoprotein quality, or the individual lipid fingerprint,” Öörni muses.
Extra info:
Lauri Äikäs et al, Icosapent ethyl–induced lipoprotein reworking and its impression on heart problems danger markers in normolipidemic people, JCI Perception (2025). DOI: 10.1172/jci.perception.193637
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Results of fish oil dietary supplements range, doubtlessly lowering heart problems danger in wholesome folks as effectively (2025, October 20)
retrieved 20 October 2025
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