Rheumatoid arthritis (RA) is related to a better fee of coronary heart failure subtypes, in response to a research printed on-line Dec. 9 in Arthritis Care & Analysis.
Yumeko Kawano, M.D., from Brigham and Girls’s Hospital in Boston, and colleagues evaluated the danger for coronary heart failure subtypes in sufferers with RA in comparison with non-RA controls. The evaluation included 1,445 sufferers with RA and 4,335 matched non-RA controls.
The researchers discovered that coronary heart failure with preserved ejection fraction (HFpEF) was the commonest coronary heart failure subtype in each teams (65% in RA versus 59% in non-RA). Sufferers with RA had a better threat for incident coronary heart failure than these with out RA (hazard ratio, 1.79) when adjusting for heart problems threat elements. Sufferers with RA additionally had a better fee of HFpEF (hazard ratio, 1.99). Nevertheless, there was no statistical distinction within the coronary heart failure with decreased ejection fraction fee.
“The elevated risk was driven by HFpEF, supporting a role for inflammation in HFpEF and highlighting potential opportunities to address this excess risk in RA,” the authors write.
“Since inflammation is modifiable with anti-inflammatory medications, further studies are needed to determine whether anti-inflammatory therapies have the potential to reduce risk of HFpEF in RA and other individuals with chronic inflammation.”
A number of authors disclosed ties to business.
Extra data:
Yumeko Kawano et al, Threat of Incident Coronary heart Failure and Coronary heart Failure Subtypes in Sufferers with Rheumatoid Arthritis, Arthritis Care & Analysis (2024). DOI: 10.1002/acr.25481
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