CI: confidence interval; COPD: power obstructive pulmonary illness; NA: not relevant. a Price ratio and 95% confidence interval obtained from a Poisson regression evaluation adjusted for intercourse, 5-year age group, immigrant standing, residence space, respiratory viral season and all threat circumstances proven within the determine. Credit score: Eurosurveillance
Amongst older adults in Spain, hospitalization charges from respiratory syncytial virus (RSV) an infection will increase progressively with age and is extra probably amongst folks with different well being points and who stay in nursing properties, in keeping with a examine printed in Eurosurveillance. The hospitalization charge diverse significantly with age and the presence of threat circumstances, with necessary implications for attainable focused interventions.
This population-based cohort examine analyzed affected person knowledge for adults over the age of 60 years in seasons 2016/17 to 2019/20 obtained by means of digital medical information from the area of Navarre in Spain, with RSV hospitalizations being confirmed with PCR testing. The typical annual incidence charge of RSV hospitalization was calculated for the pool of the 4 examine durations by dividing the overall variety of circumstances by the sum of the examine inhabitants in the beginning of every interval. The hospitalization charge for every socio-demographic and threat situation was analyzed utilizing Poisson regression.
Increased hospitalization charges with age and presence of threat circumstances
On common over 4 seasons, the examine discovered that RSV brought about 84.7 hospitalizations per 100,000 amongst folks older than 60 years, and diverse considerably relying on age and sure threat components.
The probability of hospitalization was strongly related to elevated age. In contrast with folks aged 60–64 years, the speed elevated 2-, 3-, 4- and 6- fold in folks older than 70, 75, 80 and 85 years, respectively. It reached the best charge amongst these aged 85–94, with greater than 200 RSV hospitalizations per 100,000 folks on this group. This elevated threat is perhaps defined by the gradual decline of the immune system associated to growing older.
Increased hospitalization charges had been related to a number of power circumstances, presumably resulting from a better probability of an infection and elevated severity of RSV illness. Blood most cancers was the power situation that elevated the chance of hospitalization essentially the most, multiplying it by an element of three.8. Continual obstructive pulmonary illness (COPD) was additionally an necessary threat issue. The most typical power situation in sufferers was heart problems, which doubled the chance of hospitalization for folks contaminated with RSV.
Different circumstances related to increased charges of RSV hospitalization had been purposeful dependence, bronchial asthma, extreme weight problems, diabetes and power kidney illness. Folks dwelling in nursing properties had been twice as probably as these with comparable traits who didn’t stay in these amenities to be hospitalized, which might be resulting from shut contact with caregivers and different weak folks.
Focused public well being motion may considerably cut back hospitalization charges
Primarily based on the outcomes, the authors advocate that non-pharmacological preventive measures be strengthened for the adults recognized to be on the highest threat on this examine, and that they be thought of a precedence goal inhabitants for RSV vaccination.
As their charges of hospitalization are very excessive (>0.3%), these embrace folks 60 years and older with hematological most cancers or nursing residence residence, folks older than 74 years with COPD or purposeful dependence, and folks older than 84 years with bronchial asthma or heart problems.
Primarily based on the Navarre knowledge, contemplating these threat teams as goal teams would contain immunizing solely 13% of individuals aged 60 years and older, however would deal with half of RSV hospitalizations on this age group, and will considerably cut back the burden of RSV on well being care methods and RSV-related deaths.
Extra info:
Hospitalisation resulting from respiratory syncytial virus in a population-based cohort of older adults in Spain, 2016/17 to 2019/20, Eurosurveillance (2025). DOI: 10.2807/1560-7917.ES.2025.30.10.2400364, www.eurosurveillance.org/conte … S.2025.30.10.2400364
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European Centre for Illness Prevention and Management (ECDC)
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RSV hospitalization threat amongst older adults linked to age and sure threat circumstances (2025, March 13)
retrieved 13 March 2025
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