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The European Society for Blood and Marrow Transplantation (EBMT) has launched its ninth particular report on indications for hematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) remedy. The report gives up to date steerage for clinicians treating hematological illnesses, strong tumors, and immune issues.
The work is printed within the journal Bone Marrow Transplantation.
Over the previous 20 years, EBMT has refined its suggestions to align with evolving scientific and scientific developments. The 2025 report underscores the significance of harmonizing practices throughout transplant facilities to enhance affected person outcomes and facilitate significant knowledge aggregation. It additionally highlights the rising function of progressive therapies, equivalent to CAR-T and superior remedy medicinal merchandise (ATMPs), in reworking therapy paradigms.
The manuscript outlines obtainable knowledge, common steerage, and key references, complemented by disease-specific tables that present concise suggestions for HCT and CAR-T indications primarily based on illness standing, donor availability, and degree of proof in each grownup and pediatric populations. It additionally addresses advances in gene remedy, emphasizes the significance of high quality requirements equivalent to JACIE certification, and encourages complete reporting to the EBMT Registry to strengthen real-world proof and long-term end result analysis.
A multidisciplinary strategy is beneficial to stability illness danger, procedural dangers, and various methods, with a concentrate on survival and high quality of life.
“These recommendations aim to support clinicians in optimizing treatment strategies across EBMT centers, ensuring that patients benefit from the most up-to-date advances in cellular and gene therapies,” mentioned Raffaella Greco, co-lead writer.
“Since the last edition, innovative cellular and gene therapies have entered clinical practice across several indications, significantly influencing decision-making. We strongly encourage every EBMT center to download the updated recommendations and integrate them into daily practice to ensure consistency and the highest quality of care for patients.” added Annalisa Ruggeri, co-lead writer.
Extra info:
R. Greco et al, Indications for haematopoietic cell transplantation and CAR-T for haematological illnesses, strong tumours and immune issues: 2025 EBMT apply suggestions, Bone Marrow Transplantation (2025). DOI: 10.1038/s41409-025-02701-3
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European Society for Blood and Marrow Transplantation
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Scientific apply suggestions for haematopoietic cell transplantation and CAR-T remedy, new for 2025 (2025, October 2)
retrieved 2 October 2025
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