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Cedars-Sinai researchers have developed a novel dietary components, mBiota Elemental, a palatable elemental food regimen (PED) that reduces the abundance of key intestine microbiome taxa and improves signs in sufferers with small intestinal bacterial overgrowth (SIBO) and intestinal methanogen overgrowth (IMO).
Intervention testing with mBiota Elemental confirmed normalized breath exams and reduction of signs within the majority of individuals, with no severe or extreme adversarial occasions.
Elemental diets are extremely digestible dietary formulation containing free amino acids, easy carbohydrates, minimal fats, and important micronutrients. Designed to offer full vitamin with minimal stimulation of the digestive system, elemental diets have been utilized in circumstances reminiscent of Crohn’s illness, eosinophilic esophagitis/gastroenteritis, and continual pancreatitis.
Intestinal microbial overgrowth syndromes, together with SIBO and IMO, contain abnormally excessive ranges of coliform micro organism or methanogenic archaea within the gastrointestinal tract. Antibiotics stay the first remedy, but normalization happens in solely about half of SIBO instances and fewer in IMO. Recurrence is frequent, usually requiring repeated antibiotic programs which may have deleterious results on the general microbiome.
Earlier retrospective findings instructed that elemental diets may scale back microbial overgrowth, but no potential medical trials had examined this in sufferers with SIBO or IMO. Use of elemental diets in apply has been restricted by poor palatability, which impacts adherence in each pediatric and grownup populations.
Within the research, “Effect, tolerability, and safety of exclusive palatable elemental diet in patients with intestinal microbial overgrowth,” revealed in Scientific Gastroenterology and Hepatology, researchers carried out a potential, open-label medical trial to evaluate the impact, tolerability, and security of a novel PED in grownup topics with SIBO and/or IMO.
A complete of 30 adults with confirmed diagnoses of SIBO, IMO, or each primarily based on lactulose breath exams had been enrolled. All individuals obtained a two-week course of mBiota Elemental PED, adopted by a two-week interval of normal meals reintroduction.
Researchers used structured symptom questionnaires, day by day visible analog scale rankings, stool picture evaluation by way of synthetic intelligence, breath fuel measurements, 16S rRNA gene sequencing of stool samples, and digital PCR evaluation for Methanobrevibacter smithii. Physique composition was measured with bioelectrical impedance, and blood exams had been used to watch electrolytes and glucose.
All 30 individuals accomplished the two-week trial of mBiota Elemental. Breath take a look at normalization occurred in 73% of topics. Satisfactory world reduction of signs was reported by 83%.
Important reductions in exhaled methane and hydrogen ranges had been recorded, with common most methane lowering from 41 to 12 elements per million (ppm) and hydrogen from 43 to 12 ppm. Fasting day by day methane ranges in topics with IMO or IMO/SIBO dropped beneath 5 ppm by day 5 of the intervention.
Stool microbiome evaluation revealed lowered relative abundance of key microbial teams, together with Prevotella_9 and Fusobacterium, by the tip of the trial. Digital PCR evaluation confirmed that 92% of topics with detectable
Methanobrevibacter smithii at baseline had lowered or undetectable ranges by the tip of the trial. Submit‑PED, hydrogen manufacturing shifted from an early (small‑bowel) peak to a later (colonic) rise, indicating altered fermentation geography within the intestine.
Symptom monitoring confirmed important enhancements through the PED part in bloating, distention, stomach discomfort, constipation, and flatulence. Further signs, together with stomach ache, fatigue, diarrhea, urgency, and mind fog, improved through the meals reintroduction part. Fasting electrolytes (sodium, potassium, chloride, bicarbonate) and glucose stayed inside regular ranges all through, addressing a standard security concern for elemental diets.
No severe or extreme adversarial occasions had been reported. Gentle negative effects included diarrhea, cramps, nausea, fatigue, heartburn, belching, urgency, and transient hemorrhoidal bleeding. Topics misplaced roughly 3 kg, pushed primarily by reductions in whole physique fats and visceral fats.
Findings recommend a short-term course of mBiota Elemental could provide an efficient non-antibiotic dietary method for managing SIBO and IMO.
All individuals accomplished the total course, an adherence price that the authors attribute to the improved style, odor, and texture of the components, overcoming a protracted‑standing barrier to elemental‑food regimen use.
Palatability of the components could enhance the medical utility of elemental diets for sufferers with microbial overgrowth syndromes. Additional managed trials are wanted to judge long-term outcomes and underlying mechanisms.
Extra data:
Ali Rezaie et al, Impact, tolerability, and security of unique palatable elemental food regimen in sufferers with intestinal microbial overgrowth, Scientific Gastroenterology and Hepatology (2025). DOI: 10.1016/j.cgh.2025.03.002
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