Illustration of obstruction of air flow. Credit score: Habib M’henni / public area
Individuals with obstructive sleep apnea have an elevated danger of Parkinson’s illness, but when began early sufficient, steady optimistic airway stress (CPAP) might cut back that danger, in accordance with a preliminary examine offered on the American Academy of Neurology’s 77th Annual Assembly going down April 5–9, 2025, in San Diego and on-line.
The examine discovered utilizing CPAP inside two years of a sleep apnea prognosis lowered the danger of Parkinson’s.
Obstructive sleep apnea is when throat muscle mass calm down throughout sleep, blocking the airway, inflicting an individual to get up repeatedly to breathe. This disrupted sleep sample can decrease oxygen ranges, affecting the mind. With CPAP, pressurized air is delivered by way of a masks to maintain the airway open whereas an individual sleeps.
“Obstructive sleep apnea is common and previous research has found that when untreated, it is associated with an increased risk of heart attack and stroke,” mentioned examine writer Gregory D. Scott, MD, Ph.D., of the VA Portland Well being Care System in Oregon.
For the examine, researchers reviewed greater than 20 years of medical information to determine almost 1.6 million veterans who had obstructive sleep apnea and almost 10 million veterans who didn’t.
Researchers then recognized which members developed Parkinson’s illness. Of these with sleep apnea, 5,284 folks, or 3.4%, developed Parkinson’s illness inside 5 years, in comparison with 37,873 folks, or 3.8% of those that didn’t have sleep apnea.
Nevertheless, Scott famous these preliminary proportions have been doubtlessly biased by variations in age, smoking, and total survival between the group with sleep apnea and people who didn’t have sleep apnea.
Researchers checked out charges of Parkinson’s illness 5 years after a sleep apnea prognosis. After adjusting for age, intercourse and well being elements reminiscent of smoking, researchers discovered amongst folks with sleep apnea, there have been 1.8 extra circumstances of Parkinson’s illness per 1,000 folks in comparison with folks with out sleep apnea.
Of members with sleep apnea, 10% had documented use of a CPAP machine. These members have been divided into two teams: those that acquired a CPAP machine inside two years of their prognosis and people who acquired one after two years.
Researchers discovered related charges amongst folks with sleep apnea who began CPAP after two years to those that didn’t use CPAP, with 9.5 and 9.0 circumstances of Parkinson’s illness per 1,000 folks respectively. Nevertheless, researchers discovered a decrease price of Parkinson’s amongst those that began CPAP early, inside two years of prognosis, with 2.3 fewer circumstances per 1,000 folks when in comparison with individuals who didn’t use CPAP.
“It is encouraging to know that while obstructive sleep apnea may increase the risk of Parkinson’s disease, treating it right away with CPAP may reduce that risk,” mentioned Scott. “Future studies are needed to follow people more closely after receiving a sleep apnea diagnosis and over longer periods of time.”
A limitation of the examine was that whereas researchers may determine which individuals had a CPAP system, they have been unable to inform if folks used the remedy each day, as prescribed.
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Sleep apnea linked to elevated danger of Parkinson’s: Examine suggests CPAP might cut back danger (2025, March 2)
retrieved 2 March 2025
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