Subclinical synovitis is considerably extra frequent amongst sufferers with psoriasis with out musculoskeletal involvement than wholesome controls, in accordance with a overview printed on-line July 16 in JAMA Dermatology.
Shanti Mehta, from the College of Toronto, and colleagues performed a scientific literature overview and meta-analysis to judge the prevalence of synovitis on ultrasonograms and magnetic resonance imaging (MRI) amongst sufferers with psoriasis with out musculoskeletal involvement.
Based mostly on knowledge from 12 research (1,593 sufferers with psoriasis, 327 sufferers with psoriatic arthritis, and 686 wholesome controls), the researchers discovered that synovitis was considerably extra doubtless amongst sufferers with psoriasis than controls (threat ratio, 2.55; 95% confidence interval, 1.18 to five.52).
In contrast with ultrasonography (threat ratio, 2.50; 95% confidence interval, 1.10 to five.67), detection charges had been larger with MRI (threat ratio, 6.40; 95% confidence interval, 1.87 to 21.95). Whereas not statistically vital, synovitis was extra frequent amongst sufferers with psoriatic arthritis than these with psoriasis (threat ratio, 0.50; 95% confidence interval, 0.13 to 1.87).
“This study suggests that subclinical synovitis is more prevalent among patients with psoriasis without musculoskeletal involvement than healthy controls, suggesting that imaging may help identify those at increased risk of transition to psoriatic arthritis,” the authors write.
One creator disclosed ties to AbbVie, Janssen, Novartis, Sandoz, and Amgen.
Extra info:
Shanti Mehta et al, Subclinical Synovitis Amongst Sufferers With Psoriasis With out Musculoskeletal Involvement, JAMA Dermatology (2025). DOI: 10.1001/jamadermatol.2025.2281
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Subclinical synovitis threat larger in psoriasis with out musculoskeletal involvement (2025, July 22)
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