In a particular article revealed on-line March 19 within the Journal of Medical Oncology, the American Society of Medical Oncology presents up to date suggestions for fertility preservation (FP) in folks with most cancers.
H. Irene Su, M.D., from the College of California in San Diego, and colleagues up to date the systematic assessment to supply the most recent suggestions for FP in folks with most cancers. The proof base included 166 research.
The authors really helpful that folks with most cancers needs to be assessed for and endorsed about reproductive dangers at prognosis and through survivorship. Referral to reproductive specialists needs to be provided to sufferers involved in or unsure about FP. Dialogue of FP approaches ought to happen earlier than cancer-directed remedy.
Male sufferers needs to be provided sperm cryopreservation earlier than cancer-directed therapy; if unable to supply semen samples, testicular sperm extraction ought to happen. In prepubertal males, testicular tissue cryopreservation is experimental and may solely be provided in scientific trials. Male sufferers needs to be suggested concerning the potential for increased genetic harm dangers in sperm collected quickly after initiation and completion of cancer-directed remedy.
Established FP strategies needs to be provided to feminine sufferers, together with embryo, oocyte, and ovarian tissue cryopreservation (OTC), ovarian transposition, and conservative gynecologic surgical procedure. In vitro maturation of oocytes is an rising methodology that could be provided.
Individuals who didn’t bear pretreatment FP or cryopreserve sufficient oocytes or embryos will be provided posttreatment FP. In youngsters who’ve begun puberty, established FP strategies needs to be provided with affected person assent and guardian/guardian consent. For prepubertal females, the one established methodology is OTC.
“Reproductive care should be part of the standard care of all oncology patients,” the authors write. “Clinicians should advocate for comprehensive FP services coverage and help patients access benefits.”
Among the skilled panel disclosed ties to related organizations.
Extra info:
H. Irene Su et al, Fertility Preservation in Individuals With Most cancers: ASCO Guideline Replace, Journal of Medical Oncology (2025). DOI: 10.1200/JCO-24-02782
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