Credit score: European Coronary heart Journal – Cardiovascular Imaging (2025). DOI: 10.1093/ehjci/jeaf015
A brand new examine by researchers at Karolinska Institutet and Södersjukhuset reveals that superior ultrasound imaging analyses can not establish sufferers who would profit from beta-blocker therapy after a myocardial infarction. The examine, printed within the European Coronary heart Journal—Cardiovascular Imaging, is a follow-up to the earlier REDUCE-AMI examine.
The REDUCE-AMI examine, printed in 2024 within the New England Journal of Medication, confirmed that beta-blockers haven’t any optimistic impact on sufferers with regular left ventricular perform after a myocardial infarction.
The brand new examine, led by researchers Robin Hofmann, Katarina Mars, and Martin Sundqvist, on the Division of Medical Analysis and Schooling, Södersjukhuset, investigated whether or not superior ultrasound imaging analyses, particularly international longitudinal pressure (GLS), may present extra prognostic info.
“We wanted to see if GLS could be a better prognostic marker than the traditional measurement of left ventricular function, but unfortunately, the results showed that GLS did not provide any additional valuable information,” says Robin Hofmann, Affiliate Professor on the Division of Medical Analysis and Schooling, Södersjukhuset.
The examine included 1,436 sufferers with preserved left ventricular perform after a myocardial infarction. Of those, 324 sufferers couldn’t be analyzed because of poor picture high quality or incompatible tools. The outcomes confirmed no important distinction between GLS and conventional left ventricular perform in predicting dying or new coronary heart assaults.
“Our results show that there is no added value in using GLS compared to traditional methods for assessing left ventricular function in these patients. This means that we cannot recommend the routine use of GLS to identify patients who would benefit from beta-blockers,” says Hofmann.
This examine contributes to the rising physique of proof questioning the good thing about beta-blockers in sufferers with preserved left ventricular perform after a myocardial infarction. The researchers hope that their findings will assist enhance therapy tips and affected person care sooner or later.
Extra info:
Katarina Mars et al, The prognostic worth of world longitudinal pressure in sufferers with myocardial infarction and preserved ejection fraction – a prespecified substudy of the REDUCE-AMI trial, European Coronary heart Journal – Cardiovascular Imaging (2025). DOI: 10.1093/ehjci/jeaf015
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Superior ultrasound can not discern who would profit from beta-blocker therapy after myocardial infarction (2025, January 28)
retrieved 28 January 2025
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