For sufferers with Parkinson’s illness with motor fluctuations, the oral once-daily, selective D1/D5 partial dopamine agonist tavapadon as an adjunct to levodopa will increase whole every day ON time versus placebo, in keeping with a examine introduced on the annual assembly of the American Academy of Neurology, held from April 5 to 9 in San Diego.
Hubert Fernandez, M.D., from the Cleveland Clinic, and colleagues carried out a part 3, placebo-controlled, double-blind trial to look at adjunctive remedy with tavapadon in adults experiencing motor fluctuations whereas receiving secure levodopa remedy. A complete of 507 sufferers (aged 40 to 80 years) had been enrolled and randomly assigned to adjunctive tavapadon (titrated to most tolerated versatile dose: 5 to fifteen mg every day) or placebo in a 1:1 ratio.
The researchers discovered that tavapadon remedy considerably elevated whole every day ON time with out troublesome dyskinesia (1.7 hours versus 0.6 hours with placebo). There was additionally a major discount within the change from baseline in every day OFF time in contrast with placebo. The protection profile of tavapadon was in step with that seen in earlier scientific trials; most opposed occasions had been gentle to average in severity.
“These findings in adults with Parkinson’s disease and motor fluctuations demonstrate the efficacy and acceptable safety profile of tavapadon as adjunctive therapy to levodopa,” the authors write.
Extra data:
Hubert Fernandez et al, Efficacy and Security of Tavapadon, an Orally Administered, As soon as-daily, Selective D1/D5 Partial Dopamine Agonist, Adjunctive to Levodopa for Remedy of Parkinson’s Illness with Motor Fluctuations (S37.003), Neurology (2025). DOI: 10.1212/WNL.0000000000208468
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Tavapadon as adjunct to levodopa will increase every day ON time in Parkinson’s illness (2025, April 8)
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